Literature DB >> 8335086

The lysosomal gp63-related protein in Leishmania mexicana amastigotes is a soluble metalloproteinase with an acidic pH optimum.

T Ilg1, D Harbecke, P Overath.   

Abstract

Leishmania mexicana amastigotes express a lysosomal protein, which is antigenically related to the promastigote surface metalloproteinase (gp63). It is shown that the purified gp63-related protein from amastigote is also an active metalloproteinase. The pH-optimum of the enzyme is acidic, similar to lysosomal cysteine proteinases, but distinct from the neutral to basic pH-optimum of the promastigote surface proteinase. This study appears to be the first report on a metalloproteinase with a lysosomal localization.

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Year:  1993        PMID： 8335086     DOI： 10.1016/0014-5793(93)81049-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  An axenic amastigote system for drug screening.

Authors:  H L Callahan; A C Portal; R Devereaux; M Grogl
Journal:  Antimicrob Agents Chemother       Date:  1997-04       Impact factor: 5.191

2.  Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.

Authors:  J D Hilley; J L Zawadzki; M J McConville; G H Coombs; J C Mottram
Journal:  Mol Biol Cell       Date:  2000-04       Impact factor: 4.138

3.  Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants.

Authors:  A Garami; A Mehlert; T Ilg
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

4.  Subunit vaccination of mice against new world cutaneous leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants.

Authors:  T Aebischer; M Wolfram; S I Patzer; T Ilg; M Wiese; P Overath
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

5.  Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.

Authors:  S C Ilgoutz; J L Zawadzki; J E Ralton; M J McConville
Journal:  EMBO J       Date:  1999-05-17       Impact factor: 11.598

6.  Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.

Authors:  Manjusha M Kulkarni; Joseph Barbi; W Robert McMaster; Richard L Gallo; Abhay R Satoskar; Bradford S McGwire
Journal:  Cell Microbiol       Date:  2011-04-28       Impact factor: 3.715

7.  Surface Zn-proteinase as a molecule for defense of Leishmania mexicana amazonensis promastigotes against cytolysis inside macrophage phagolysosomes.

Authors:  M B Seay; P L Heard; G Chaudhuri
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

8.  Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein.

Authors:  Sally Corradin; Adriana Ransijn; Giampietro Corradin; Jacques Bouvier; Maria Belen Delgado; Jimena Fernandez-Carneado; Jeremy C Mottram; Guy Vergères; Jacques Mauël
Journal:  Biochem J       Date:  2002-11-01       Impact factor: 3.857

9.  The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi.

Authors:  Chia-Hung Christine Hsiao; Chaoqun Yao; Patricia Storlie; John E Donelson; Mary E Wilson
Journal:  Mol Biochem Parasitol       Date:  2007-10-30       Impact factor: 1.759

10.  Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

Authors:  N D Connell; E Medina-Acosta; W R McMaster; B R Bloom; D G Russell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205
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