Literature DB >> 8332560

Melanin-concentrating hormone in the human brain.

T Mouri1, K Takahashi, H Kawauchi, M Sone, K Totsune, O Murakami, K Itoi, M Ohneda, H Sasano, N Sasano.   

Abstract

The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive peak in the position of human/rat MCH, which was eluted 9 min later than that of salmon MCH. Free-floating sections (40 microns) of the hypothalamus were immunostained. Positive MCH immunostaining was found in perifornical, tuberomammillary, and posterior nuclei. Numerous MCH-immunoreactive nerve fibers were observed throughout the hypothalamus. The presence of high concentrations of MCH in the human brain, in particular in the hypothalamus, suggests that MCH is a neurotransmitter, a neuromodulator, or a neurohormone in man.

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Year:  1993        PMID： 8332560     DOI： 10.1016/0196-9781(93)90158-d

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  10 in total

Review 1.  Lateral hypothalamic area neuropeptides modulate ventral tegmental area dopamine neurons and feeding.

Authors:  Patricia Perez-Bonilla; Krystal Santiago-Colon; Gina M Leinninger
Journal:  Physiol Behav       Date:  2020-05-31

Review 2.  Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders.

Authors:  Toshiharu Shimazaki; Takao Yoshimizu; Shigeyuki Chaki
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

3.  Microinjections of melanin concentrating hormone into the nucleus tractus solitarius of the rat elicit depressor and bradycardic responses.

Authors:  S N Brown; V C Chitravanshi; K Kawabe; H N Sapru
Journal:  Neuroscience       Date:  2007-10-05       Impact factor: 3.590

4.  The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.

Authors:  Hiroshi Nagasaki; Shinjae Chung; Colette T Dooley; Zhiwei Wang; Chunying Li; Yumiko Saito; Stewart D Clark; Richard A Houghten; Olivier Civelli
Journal:  Eur J Pharmacol       Date:  2008-11-17       Impact factor: 4.432

5.  The melanin-concentrating hormone system modulates cocaine reward.

Authors:  Shinjae Chung; F Woodward Hopf; Hiroshi Nagasaki; Chun-Ying Li; James D Belluzzi; Antonello Bonci; Olivier Civelli
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-02       Impact factor: 11.205

6.  Acute homeostatic responses to increased fat consumption in MCH1R knockout mice.

Authors:  Shinjae Chung; Timothy Wong; Hiroshi Nagasaki; Olivier Civelli
Journal:  J Mol Neurosci       Date:  2010-04-22       Impact factor: 3.444

7.  Melanin-concentrating hormone: a new sleep factor?

Authors:  Pablo Torterolo; Patricia Lagos; Jaime M Monti
Journal:  Front Neurol       Date:  2011-03-18       Impact factor: 4.003

Review 8.  To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.

Authors:  Juliette A Brown; Hillary L Woodworth; Gina M Leinninger
Journal:  Front Syst Neurosci       Date:  2015-02-18

9.  Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human.

Authors:  Katalin Skrapits; Vivien Kanti; Zsófia Savanyú; Csilla Maurnyi; Ottó Szenci; András Horváth; Beáta Á Borsay; László Herczeg; Zsolt Liposits; Erik Hrabovszky
Journal:  Front Cell Neurosci       Date:  2015-09-04       Impact factor: 5.505

10.  The Melanin-concentrating Hormone System in Human, Rodent and Avian Brain.

Authors:  János Bencze; Krisztina Pocsai; Balázs Murnyák; Péter Attila Gergely; Béla Juhász; Zoltán Szilvássy; Tibor Hortobágyi
Journal:  Open Med (Wars)       Date:  2018-07-06
  10 in total

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