Literature DB >> 8332543

Ethanol and diazepam inhibition of hippocampal LTP is mediated by angiotensin II and AT1 receptors.

M J Wayner1, D L Armstrong, J L Polan-Curtain, J B Denny.   

Abstract

Angiotensin II (AII) inhibits the induction of hippocampal long-term potentiation (LTP), a frequency-dependent model of learning and memory. These results demonstrate that the dose-dependent inhibition of LTP due to ethanol (EtOH) and diazepam (DZ) involves AII. Inhibition of LTP induction by AII, EtOH, and DZ can be blocked by AII receptor antagonists saralasin and lorsartan (DuP 753). Lorsartan is a competitive antagonist of the AT1 subtype AII receptor. Therefore, the EtOH and DZ inhibition of LTP induction is mediated by AT1 receptors. These results indicate a new role for AII in the brain in the possible mediation of memory deficits associated with alcohol and the benzodiazepines.

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Year:  1993        PMID： 8332543     DOI： 10.1016/0196-9781(93)90129-5

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  10 in total

1.  Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats.

Authors:  Nicolas Pelisch; Naohisa Hosomi; Masaki Ueno; Daisuke Nakano; Hirofumi Hitomi; Masaki Mogi; Kenji Shimada; Hiroyuki Kobori; Masatsugu Horiuchi; Haruhiko Sakamoto; Masayasu Matsumoto; Masakazu Kohno; Akira Nishiyama
Journal:  Am J Hypertens       Date:  2010-12-16       Impact factor: 2.689

Review 2.  Synaptic effects induced by alcohol.

Authors:  David M Lovinger; Marisa Roberto
Journal:  Curr Top Behav Neurosci       Date:  2013

Review 3.  Do angiotensin receptor blockers protect against Alzheimer's disease?

Authors:  Hitomi Kurinami; Munehisa Shimamura; Naoyuki Sato; Hironori Nakagami; Ryuichi Morishita
Journal:  Drugs Aging       Date:  2013-06       Impact factor: 3.923

Review 4.  Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets.

Authors:  John W Wright; Brent J Yamamoto; Joseph W Harding
Journal:  Prog Neurobiol       Date:  2007-11-19       Impact factor: 11.685

5.  Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.

Authors:  Jane Tchekalarova; Natasha Ivanova; Daniela Pechlivanova; Kalina Ilieva; Milena Atanasova
Journal:  Cell Mol Neurobiol       Date:  2013-10-22       Impact factor: 5.046

6.  Ability of angiotensin II to modulate striatal dopamine release via the AT1 receptor in vitro and in vivo.

Authors:  D C Brown; L J Steward; J Ge; N M Barnes
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739

7.  Ethanol acutely inhibits ionotropic glutamate receptor-mediated responses and long-term potentiation in the developing CA1 hippocampus.

Authors:  Michael P Puglia; C Fernando Valenzuela
Journal:  Alcohol Clin Exp Res       Date:  2010-01-26       Impact factor: 3.455

8.  Ethanol effects on dentate granule cell LTP.

Authors:  M J Wayner; D L Armstrong; C F Phelix
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.978

9.  Interactions of a Dopamine D1 Receptor Agonist with Glutamate NMDA Receptor Antagonists on the Volitional Consumption of Ethanol by the mHEP Rat.

Authors:  Brian A McMillen; Courtney L Lommatzsch; Michael J Sayonh; Helen L Williams
Journal:  Pharmaceuticals (Basel)       Date:  2013-03-26

Review 10.  Brain renin angiotensin in disease.

Authors:  M Ian Phillips; Edilamar Menezes de Oliveira
Journal:  J Mol Med (Berl)       Date:  2008-04-02       Impact factor: 4.599
  10 in total

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