Literature DB >> 8330756

Heterogeneity of NGF-induced differentiation in PC12 cells investigated in a battery of isolated cell clones.

E Clementi1, M Raichman, J Meldolesi.   

Abstract

The effect of NGF on a set of 17 PC12 cell clones was investigated in order to clarify some aspects concerning the changes in cell morphology and Ca2+ homeostasis that occur in the PC12 cell line after NGF-induced differentiation. The morphological parameters analyzed showed a high degree of heterogeneity among clones, consisting with a different expression of the high-affinity NGF receptor. The NGF effect on Ca2+ influx was investigated in a clone highly sensitive to the cholinergic agonist carbachol. Results showed an increase in Ca2+ influx through one of the carbachol-activated Ca2+ channels.

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Year:  1993        PMID： 8330756

Source DB:  PubMed          Journal:  Funct Neurol        ISSN： 0393-5264


  3 in total

1.  Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones.

Authors:  C Leoni; A Menegon; F Benfenati; D Toniolo; M Pennuto; F Valtorta
Journal:  Mol Biol Cell       Date:  1999-09       Impact factor: 4.138

2.  Image-derived models of cell organization changes during differentiation and drug treatments.

Authors:  Xiongtao Ruan; Gregory R Johnson; Iris Bierschenk; Roland Nitschke; Melanie Boerries; Hauke Busch; Robert F Murphy
Journal:  Mol Biol Cell       Date:  2019-11-27       Impact factor: 4.138

3.  High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.

Authors:  Kyle S Hubbard; Ian M Gut; Megan E Lyman; Kaylie M Tuznik; Mariano T Mesngon; Patrick M McNutt
Journal:  BMC Neurosci       Date:  2012-10-24       Impact factor: 3.288
  3 in total

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