Literature DB >> 8330180

Pharmacological study of the internal and sphincter in patients with chronic anal fissure.

F S Regadas1, L K Batista, J L Albuquerque, F R Capaz.   

Abstract

A pharmacological study of the internal anal sphincter (IAS) was undertaken in patients with chronic and fissure. The sensitivity of the IAS to the contractile effect of phenylephrine and potassium chloride and to relaxation by isoproterenol was evaluated. Supersensitivity of the IAS to relaxation by isoproterenol was noted. Further research is necessary to determine the pharmacological basis of such a disturbance.

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Year:  1993        PMID: 8330180     DOI: 10.1002/bjs.1800800650

Source DB:  PubMed          Journal:  Br J Surg        ISSN: 0007-1323            Impact factor:   6.939


  5 in total

Review 1.  Neuromyogenic properties of the internal anal sphincter: therapeutic rationale for anal fissures.

Authors:  R Bhardwaj; C J Vaizey; P B Boulos; C H Hoyle
Journal:  Gut       Date:  2000-06       Impact factor: 23.059

2.  Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.

Authors:  M K Mundey; M Jonas; T Worthley; J H Scholefield; V G Wilson
Journal:  Br J Pharmacol       Date:  2000-06       Impact factor: 8.739

3.  Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles.

Authors:  Changyoon Baek; MeeRee Han; Junhong Min; Mark R Prausnitz; Jung-Hwan Park; Jung Ho Park
Journal:  J Control Release       Date:  2011-05-07       Impact factor: 9.776

4.  Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence.

Authors:  M J Cheetham; M A Kamm; R K Phillips
Journal:  Gut       Date:  2001-03       Impact factor: 23.059

5.  The efficacy and adverse effects of topical phenylephrine for anal incontinence after low anterior resection in patients with rectal cancer.

Authors:  Jun-Seok Park; Sung-Bum Kang; Duck-Woo Kim; Hyung-Wook Namgung; Hye-Lin Kim
Journal:  Int J Colorectal Dis       Date:  2007-06-12       Impact factor: 2.571

  5 in total

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