Literature DB >> 8330

Influence of castration and testosterone replacement on hypothalamic tyrosine hydroxylase activity in the rat.

C W Beattie, M M Martin.   

Abstract

Hypothalamic tyrosine hydroxylase (TH) activity of castrate rats is modulated by testosterone propionate (TP) in vivo. Kinetic studies revealed that both Vmax and Km were virtually unaltered for substrate tyrosine in the presence of an excess of DMPH4 cofactor. TP replacement to castrate rats increased the Km for added DMPH4 cofactor, while Vmax decreased. These results suggest that TP decreases TH activity of castrate rats by inhibiting the enzyme-reduced pteridine cofactor complex.

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Year:  1976        PMID： 8330     DOI： 10.1007/BF01933981

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  A fluorometric method for the estimation of tyrosine in plasma and tissues.

Authors:  T P WAALKES; S UDENFRIEND
Journal:  J Lab Clin Med       Date:  1957-11

2.  Tyrosine hydroxylase inhibitors.

Authors:  K E Moore; J A Dominic
Journal:  Fed Proc       Date:  1971 May-Jun

3.  Pteridines as cofactor or inhibitor of tyrosine hydroxylase.

Authors:  T Nagatsu; K Mizutani; I Nagatsu; S Matsuura; T Sugimoto
Journal:  Biochem Pharmacol       Date:  1972-07-15       Impact factor: 5.858

4.  Influence of ovariectomy and ovarian steroids on hypothalamic tyrosine hydroxylase activity in the rat.

Authors:  C W Beattie; C H Rodgers; L F Soyka
Journal:  Endocrinology       Date:  1972-07       Impact factor: 4.736

5.  Allosteric activation of hypothalamic tyrosine hydroxylase by ions and sulphated mucopolysaccharides.

Authors:  R T Kuczenski; A J Mandell
Journal:  J Neurochem       Date:  1972-01       Impact factor: 5.372

6.  Increase in tyrosine hydroxylase activity after reserpine administration.

Authors:  R A Mueller; H Thoenen; J Axelrod
Journal:  J Pharmacol Exp Ther       Date:  1969-09       Impact factor: 4.030

7.  Influence of progestational steroids on hypothalamic tyrosine hydroxylase activity in vitro.

Authors:  C W Beattie; L F Soyka
Journal:  Endocrinology       Date:  1973-12       Impact factor: 4.736

8.  Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.

Authors:  J Glowinski; L L Iversen
Journal:  J Neurochem       Date:  1966-08       Impact factor: 5.372
  8 in total
  2 in total

Review 1.  Tyrosine hydroxylase regulation in the central nervous system.

Authors:  J M Masserano; N Weiner
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

2.  Hippocampal testosterone relates to reference memory performance and synaptic plasticity in male rats.

Authors:  Kristina Schulz; Volker Korz
Journal:  Front Behav Neurosci       Date:  2010-12-17       Impact factor: 3.558
  2 in total

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