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Literature DB >> 8328788

Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis.

J Beyer¹, G Barzen, G Risse, C Weyer, K Miksits, K Dullenkopf, D Huhn, W Siegert.

Abstract

The pharmacokinetics and applicability of aerosol amphotericin B administrations were studied in 40 neutropenic patients and 4 healthy volunteers. Particle size was measured and pulmonary deposition was demonstrated by radioisotope studies. Inhalations were easy to administer and were well tolerated, with minimal systemic absorption of the drug.

Entities: Chemical Disease Species

Mesh：

Substances：
Aerosols
Amphotericin B

Year: 1993 PMID： 8328788 PMCID： PMC187968 DOI： 10.1128/AAC.37.6.1367

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. Nebulized amphotericin B as prophylaxis against invasive aspergillosis in granulocytopenic patients.

Authors: E Conneally; M T Cafferkey; P A Daly; C T Keane; S R McCann
Journal: Bone Marrow Transplant Date: 1990-06 Impact factor: 5.483

Review 2. Nosocomial aspergillosis: environmental microbiology, hospital epidemiology, diagnosis and treatment.

Authors: T J Walsh; D M Dixon
Journal: Eur J Epidemiol Date: 1989-06 Impact factor: 8.082

3. Failure of amphotericin B spray to prevent aspergillosis in granulocytopenic patients.

Authors: C J Jorgensen; F Dreyfus; J Vaixeler; S Guyomard; C Massiot; C Belanger; F Brunet; T Giraud; P Dupuis-Camay
Journal: Nouv Rev Fr Hematol Date: 1989

4. Interventional antimicrobial strategy in febrile neutropenic patients. Results of a multicenter study in 1,260 patients with hematological malignancies. The Interventional Antimicrobial Strategy Study Group, Paul Ehrlich Society for Chemotherapy.

Authors: G Maschmeyer; H Link; W Hiddemann; P Meyer; M Helmerking; D Adam
Journal: Onkologie Date: 1990-02

5. Nosocomial pneumonia in adult patients undergoing bone marrow transplantation: a 9-year study.

Authors: C S Pannuti; R D Gingrich; M A Pfaller; R P Wenzel
Journal: J Clin Oncol Date: 1991-01 Impact factor: 44.544

6. Pharmacokinetics of aerosol amphotericin B in rats.

Authors: Y Niki; E M Bernard; H J Schmitt; W P Tong; F F Edwards; D Armstrong
Journal: Antimicrob Agents Chemother Date: 1990-01 Impact factor: 5.191

Review 7. New methods for delivery of antifungal agents.

Authors: F Meunier
Journal: Rev Infect Dis Date: 1989 Nov-Dec

8. A pilot study of prophylactic aerosolized amphotericin B in patients at risk for prolonged neutropenia.

Authors: S E Myers; S M Devine; R L Topper; M Ondrey; C Chandler; K O'Toole; S F Williams; R A Larson; R B Geller
Journal: Leuk Lymphoma Date: 1992-10

9. Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis.

Authors: H J Schmitt; E M Bernard; M Häuser; D Armstrong
Journal: Antimicrob Agents Chemother Date: 1988-11 Impact factor: 5.191

10. Quantitation of amphotericin B with use of high-pressure liquid chromatography.

Authors: I Nilsson-Ehle; T T Yoshikawa; J E Edwards; M C Schotz; L B Guze
Journal: J Infect Dis Date: 1977-03 Impact factor: 5.226

15 in total

Review 1. Antifungal prophylaxis during neutropenia and immunodeficiency.

Authors: O Lortholary; B Dupont
Journal: Clin Microbiol Rev Date: 1997-07 Impact factor: 26.132

2. Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients.

Authors: Z Erjavec; G M Woolthuis; H G de Vries-Hospers; W J Sluiter; S M Daenen; B de Pauw; M R Halie
Journal: Eur J Clin Microbiol Infect Dis Date: 1997-05 Impact factor: 3.267

10. Accumulation of amphotericin B in human macrophages enhances activity against Aspergillus fumigatus conidia: quantification of conidial kill at the single-cell level.

Authors: B Jahn; A Rampp; C Dick; A Jahn; M Palmer; S Bhakdi
Journal: Antimicrob Agents Chemother Date: 1998-10 Impact factor: 5.191

Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis.

1. Nebulized amphotericin B as prophylaxis against invasive aspergillosis in granulocytopenic patients.

Review 2. Nosocomial aspergillosis: environmental microbiology, hospital epidemiology, diagnosis and treatment.

3. Failure of amphotericin B spray to prevent aspergillosis in granulocytopenic patients.

4. Interventional antimicrobial strategy in febrile neutropenic patients. Results of a multicenter study in 1,260 patients with hematological malignancies. The Interventional Antimicrobial Strategy Study Group, Paul Ehrlich Society for Chemotherapy.

5. Nosocomial pneumonia in adult patients undergoing bone marrow transplantation: a 9-year study.

6. Pharmacokinetics of aerosol amphotericin B in rats.

Review 7. New methods for delivery of antifungal agents.

8. A pilot study of prophylactic aerosolized amphotericin B in patients at risk for prolonged neutropenia.

9. Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis.

10. Quantitation of amphotericin B with use of high-pressure liquid chromatography.

Review 1. Antifungal prophylaxis during neutropenia and immunodeficiency.

2. Tolerance and efficacy of Amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in haematological patients.

Review 3. Aspergillus infections in transplant recipients.

Review 4. Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patients.

Review 5. Aspergillus fumigatus and aspergillosis.

6. Efficacy of prophylactic aerosol amphotericin B lipid complex in a rat model of pulmonary aspergillosis.

7. Aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients.

Review 8. Prevention and therapy of fungal infections in cancer patients. A review of recently published information.

Review 9. Use of amphotericin B aerosols for the prevention of pulmonary aspergillosis.

10. Accumulation of amphotericin B in human macrophages enhances activity against Aspergillus fumigatus conidia: quantification of conidial kill at the single-cell level.