Literature DB >> 8327462

Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation?

E Wieland1, S Parthasarathy, D Steinberg.   

Abstract

Oxidative modification of low density lipoprotein is believed to be an important pathway by which the lipoprotein becomes atherogenic. The in vitro systems for oxidative modification of low density lipoprotein thus far described all appear to depend upon the presence in the medium of free transition metal ions (copper or iron). In vivo, on the other hand, these metals are present almost exclusively in tightly complexed forms that do not catalyze oxidative modification. The present studies describe oxidation of low density lipoprotein in a simple system that does not depend upon the presence of added free metal ions. It requires the presence of horseradish peroxidase and either hydrogen peroxide or lipid hydroperoxides.

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Year:  1993        PMID： 8327462      PMCID： PMC46840          DOI： 10.1073/pnas.90.13.5929

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  29 in total

1.  The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.

Authors:  R J HAVEL; H A EDER; J H BRAGDON
Journal:  J Clin Invest       Date:  1955-09       Impact factor: 14.808

2.  Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase.

Authors:  V M Samokyszyn; L J Marnett
Journal:  J Biol Chem       Date:  1987-10-15       Impact factor: 5.157

3.  Carbon-centered free radical intermediates in the hematin- and ram seminal vesicle-catalyzed decomposition of fatty acid hydroperoxides.

Authors:  J Schreiber; R P Mason; T E Eling
Journal:  Arch Biochem Biophys       Date:  1986-11-15       Impact factor: 4.013

4.  Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.

Authors:  R R Montgomery; C F Nathan; Z A Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

5.  Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

Authors:  S Ohki; N Ogino; S Yamamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1979-02-10       Impact factor: 5.157

6.  Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

Authors:  S Parthasarathy; D J Printz; D Boyd; L Joy; D Steinberg
Journal:  Arteriosclerosis       Date:  1986 Sep-Oct

7.  Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

Authors:  T E Carew; D C Schwenke; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

8.  Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

Authors:  T Kita; Y Nagano; M Yokode; K Ishii; N Kume; A Ooshima; H Yoshida; C Kawai
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

9.  Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

Authors:  U P Steinbrecher; S Parthasarathy; D S Leake; J L Witztum; D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

10.  A novel mechanism by which probucol lowers low density lipoprotein levels demonstrated in the LDL receptor-deficient rabbit.

Authors:  M Naruszewicz; T E Carew; R C Pittman; J L Witztum; D Steinberg
Journal:  J Lipid Res       Date:  1984-11       Impact factor: 5.922
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  9 in total

1.  Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces.

Authors:  C K Mukhopadhyay; B Mazumder; P F Lindley; P L Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 2.  Oxidized low-density lipoprotein.

Authors:  Sampath Parthasarathy; Achuthan Raghavamenon; Mahdi Omar Garelnabi; Nalini Santanam
Journal:  Methods Mol Biol       Date:  2010

Review 3.  Lipid peroxidation and decomposition--conflicting roles in plaque vulnerability and stability.

Authors:  Sampath Parthasarathy; Dmitry Litvinov; Krithika Selvarajan; Mahdi Garelnabi
Journal:  Biochim Biophys Acta       Date:  2008-03-25

4.  Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases.

Authors:  N Santanam; S Parthasarathy
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

5.  Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation.

Authors:  L J Hazell; J J van den Berg; R Stocker
Journal:  Biochem J       Date:  1994-08-15       Impact factor: 3.857

6.  Enzymatically modified low-density lipoprotein is recognized by c1q and activates the classical complement pathway.

Authors:  Gérard J Arlaud; Adrienn Biro; Wai Li Ling
Journal:  J Lipids       Date:  2011-03-09

7.  Impact of Oxidative Stress in Premature Aging and Iron Overload in Hemodialysis Patients.

Authors:  Blanca Murillo-Ortiz; Joel Ramírez Emiliano; Wendy Ivett Hernández Vázquez; Sandra Martínez-Garza; Sergio Solorio-Meza; Froylán Albarrán-Tamayo; Edna Ramos-Rodríguez; Luis Benítez-Bribiesca
Journal:  Oxid Med Cell Longev       Date:  2016-10-05       Impact factor: 6.543

8.  oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages.

Authors:  Stefan Wallner; Margot Grandl; Gerhard Liebisch; Markus Peer; Evelyn Orsó; Alexander Sigrüner; Andrzej Sobota; Gerd Schmitz
Journal:  PLoS One       Date:  2016-11-21       Impact factor: 3.240

9.  On the pathogenesis of atherosclerosis: enzymatic transformation of human low density lipoprotein to an atherogenic moiety.

Authors:  S Bhakdi; B Dorweiler; R Kirchmann; J Torzewski; E Weise; J Tranum-Jensen; I Walev; E Wieland
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307
  9 in total

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