Literature DB >> 8326745

Inhibition of iron absorption prolongs the life span of Drosophila.

H R Massie1, V R Aiello, T R Williams.   

Abstract

The life span of Drosophila melanogaster (Oregon R) males was found to be proportional to the logarithm of the iron content of the diet. Life span was also shown to be proportional to the rate of iron accumulation for Drosophila, mice and man. The total body iron content was found to correlate with the total calcium content of adult Drosophila. Iron content during the developmental stages, however, remained relatively constant and did not change with changes in the calcium concentrations. Dietary tea (Camellia sinensis) extracts were found to inhibit the ageing-related accumulation of iron and to prolong the life span of Drosophila by as much as 21.4%. It is concluded that iron accumulation is a significant factor contributing to senescence.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8326745     DOI： 10.1016/0047-6374(93)90001-8

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  22 in total

Review 1.  Aging and immune function: molecular mechanisms to interventions.

Authors:  Subramaniam Ponnappan; Usha Ponnappan
Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

Review 2.  The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.

Authors:  Jinze Xu; Emanuele Marzetti; Arnold Y Seo; Jae-Sung Kim; Tomas A Prolla; Christiaan Leeuwenburgh
Journal:  Mech Ageing Dev       Date:  2010-04-29       Impact factor: 5.432

3.  Age-dependent and gender-specific changes in mouse tissue iron by strain.

Authors:  Paul Hahn; Ying Song; Gui-shuang Ying; Xining He; John Beard; Joshua L Dunaief
Journal:  Exp Gerontol       Date:  2009-06-27       Impact factor: 4.032

4.  Changes in the expression of four heat shock proteins during the aging process in Brachionus calyciflorus (rotifera).

Authors:  Jianghua Yang; Yawen Mu; Siming Dong; Qichen Jiang; Jiaxin Yang
Journal:  Cell Stress Chaperones       Date:  2013-04-26       Impact factor: 3.667

5.  Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat.

Authors:  Samuel E Schriner; Niki S Katoozi; Kevin Q Pham; Maral Gazarian; Asghar Zarban; Mahtab Jafari
Journal:  Biogerontology       Date:  2011-09-18       Impact factor: 4.277

6.  Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster.

Authors:  Terry E Lopez; Hoang M Pham; Benjamin V Nguyen; Yerazik Tahmasian; Shannon Ramsden; Volkan Coskun; Samuel E Schriner; Mahtab Jafari
Journal:  Arch Insect Biochem Physiol       Date:  2016-10-03       Impact factor: 1.698

Review 7.  Iron homeostasis and toxicity in retinal degeneration.

Authors:  Xining He; Paul Hahn; Jared Iacovelli; Robert Wong; Chih King; Robert Bhisitkul; Mina Massaro-Giordano; Joshua L Dunaief
Journal:  Prog Retin Eye Res       Date:  2007-08-11       Impact factor: 21.198

8.  Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness.

Authors:  Terry Lopez; Samuel E Schriner; Michael Okoro; David Lu; Beatrice T Chiang; Jocelyn Huey; Mahtab Jafari
Journal:  J Med Food       Date:  2014-12       Impact factor: 2.786

9.  Evidence for metabolic provisioning by a common invertebrate endosymbiont, Wolbachia pipientis, during periods of nutritional stress.

Authors:  Jeremy C Brownlie; Bodil N Cass; Markus Riegler; Joris J Witsenburg; Iñaki Iturbe-Ormaetxe; Elizabeth A McGraw; Scott L O'Neill
Journal:  PLoS Pathog       Date:  2009-04-03       Impact factor: 6.823

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.