Literature DB >> 8325375

Cotranslational heme binding to nascent globin chains.

A A Komar1, A Kommer, I A Krasheninnikov, A S Spirin.   

Abstract

Globin synthesis in cell-free extracts of rabbit reticulocytes was carried out in the presence of 3H-labeled hemin. Sucrose gradient centrifugation analysis revealed [3H]hemin in the polyribosome fraction. The addition of puromycin resulted in the release of both [3H]hemin- and [14C]leucine-labeled polypeptide from the polyribosomes. The data suggest cotranslational folding of the globin molecule on the ribosome and cotranslational heme binding to the nascent globin chain.

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Year:  1993        PMID： 8325375     DOI： 10.1016/0014-5793(93)81803-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

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Authors:  R Gilmore; M C Coffey; G Leone; K McLure; P W Lee
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

5.  The Interplay between Molten Globules and Heme Disassociation Defines Human Hemoglobin Disassembly.

Authors:  Premila P Samuel; Mark A White; William C Ou; David A Case; George N Phillips; John S Olson
Journal:  Biophys J       Date:  2020-02-04       Impact factor: 4.033

6.  Haem disorder in recombinant- and reticulocyte-derived haemoglobins: evidence for stereoselective haem insertion in eukaryotes.

Authors:  A J Mathews; T Brittain
Journal:  Biochem J       Date:  2001-07-01       Impact factor: 3.857

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Authors:  Anton A Komar
Journal:  Methods       Date:  2017-12-06       Impact factor: 3.608

8.  Aplysia limacina myoglobin cDNA cloning: an alternative mechanism of oxygen stabilization as studied by active-site mutagenesis.

Authors:  F Cutruzzolà; C Travaglini Allocatelli; A Brancaccio; M Brunori
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

Review 9.  The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly.

Authors:  Todd L Mollan; Xiang Yu; Mitchell J Weiss; John S Olson
Journal:  Antioxid Redox Signal       Date:  2010-02       Impact factor: 8.401

10.  NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center.

Authors:  S Wang; H Sakai; M Wiedmann
Journal:  J Cell Biol       Date:  1995-08       Impact factor: 10.539
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