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Literature DB >> 8324335

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice.

T Furukawa¹, T Kubota, M Watanabe, T H Kuo, H Nishibori, S Kase, Y Saikawa, H Tanino, T Teramoto, K Ishibiki.

Abstract

COL-2-JCK, a human colon cancer xenograft line able to be transplanted into nude mice, was implanted in the subserosal layer of the cecum, either as cancer tissue or as a single cell suspension. When cancer tissue was used for the cecal implantation, 100% extensive local tumor growth and a high incidence of metastases to the regional lymph nodes, peritoneum, liver, and lung was observed. In contrast, when the cell suspension of this line was injected into the cecal wall, no metastases were observed, with significantly reduced local tumor growth. The use of cancer tissue maintaining the original cancer tissue structure is therefore considered imperative for allowing full expression of the biological characteristics of cancer cells. This nude mouse model using the cecal implantation of cancer tissue should thus prompt further study on the biology of human colon cancer.

Entities: Disease Gene Species

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Year: 1993 PMID： 8324335 DOI： 10.1007/bf00309500

Source DB: PubMed Journal: Surg Today ISSN： 0941-1291 Impact factor: 2.549

18 in total

1. [Expression of malignant potential of human colon cancer in nude mice: preliminary report].

Authors: Y Yamada; K Nakatani; A Watanabe; T Okumura; T Yano; Y Yamada; H Nakano
Journal: Nihon Geka Gakkai Zasshi Date: 1990-06

2. Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice.

Authors: X Y Fu; D Theodorescu; R S Kerbel; R M Hoffman
Journal: Int J Cancer Date: 1991-12-02 Impact factor: 7.396

Review 3. Three-dimensional histoculture: origins and applications in cancer research.

Authors: R M Hoffman
Journal: Cancer Cells Date: 1991-03

4. Anti-angiogenesis: new concept for therapy of solid tumors.

Authors: J Folkman
Journal: Ann Surg Date: 1972-03 Impact factor: 12.969

5. Development of invasive tumors in the "nude" mouse after injection of cultured human melanoma cells.

Authors: B C Giovanella; S O Yim; J S Stehlin; L J Williams
Journal: J Natl Cancer Inst Date: 1972-05 Impact factor: 13.506

6. In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.

Authors: K Morikawa; S M Walker; J M Jessup; I J Fidler
Journal: Cancer Res Date: 1988-04-01 Impact factor: 12.701

5. Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research.

Authors: David H Lum; Cindy Matsen; Alana L Welm; Bryan E Welm
Journal: Curr Protoc Pharmacol Date: 2012-12

5 in total

A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice.

1. [Expression of malignant potential of human colon cancer in nude mice: preliminary report].

2. Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice.

Review 3. Three-dimensional histoculture: origins and applications in cancer research.

4. Anti-angiogenesis: new concept for therapy of solid tumors.

5. Development of invasive tumors in the "nude" mouse after injection of cultured human melanoma cells.

6. In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.

7. A new animal model for human colon cancer metastasis.

8. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

9. Experimental nude mouse model of human colorectal cancer liver metastases.

10. Transplantation of human tumors in nude mice.

1. Establishment of a human cancer cell line with high potential for peritoneal dissemination.

2. Increased peritoneal dissemination after laparotomy versus pneumoperitoneum in a mouse cecal cancer model.

3. High antimetastatic efficacy of MEN4901/T-0128, a novel camptothecin carboxymethyldextran conjugate.

Review 4. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic.

5. Overview of human primary tumorgraft models: comparisons with traditional oncology preclinical models and the clinical relevance and utility of primary tumorgrafts in basic and translational oncology research.