Literature DB >> 8321859

Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography.

M Yokoyama1, T Sugiyama, T Okano, Y Sakurai, M Naito, K Kataoka.   

Abstract

The micelle-forming behavior of a drug-block copolymer conjugate (adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer; PEG-P[Asp(ADR)]) was analyzed by gel permeation chromatography (GPC). Four compositions of the conjugates were observed to form micellar structures in aqueous media, and their micelle-forming behavior was found to be dependent on the composition and media. These micelles did not reach equilibrium within short time periods like low molecular weight surfactants. One composition formed stable micelles in the presence of serum.

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Year:  1993        PMID： 8321859     DOI： 10.1023/a:1018921513605

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  5 in total

1.  Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.

Authors:  M Yokoyama; T Okano; Y Sakurai; H Ekimoto; C Shibazaki; K Kataoka
Journal:  Cancer Res       Date:  1991-06-15       Impact factor: 12.701

2.  The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting.

Authors:  A V Kabanov; V P Chekhonin; E V Batrakova; A S Lebedev; N S Melik-Nubarov; S A Arzhakov; A V Levashov; G V Morozov; E S Severin
Journal:  FEBS Lett       Date:  1989-12-04       Impact factor: 4.124

Review 3.  Macromolecule-drug conjugates in targeted cancer chemotherapy.

Authors:  H Sezaki; M Hashida
Journal:  Crit Rev Ther Drug Carrier Syst       Date:  1984       Impact factor: 4.889

4.  A novel covalent modification of antibodies at their amino groups with retention of antigen-binding activity.

Authors:  N Endo; N Umemoto; Y Kato; Y Takeda; T Hara
Journal:  J Immunol Methods       Date:  1987-11-23       Impact factor: 2.303

5.  Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.

Authors:  R Duncan; P Kopecková-Rejmanová; J Strohalm; I Hume; H C Cable; J Pohl; J B Lloyd; J Kopecek
Journal:  Br J Cancer       Date:  1987-02       Impact factor: 7.640
  5 in total
  14 in total

1.  The stabilization and release of hirudin from liposomes or lipid-assemblies coated with hydrophobically modified dextran.

Authors:  R J Mumper; A S Hoffman
Journal:  AAPS PharmSciTech       Date:  2000-03-03       Impact factor: 3.246

2.  Enhanced stability of polymeric micelles based on postfunctionalized poly(ethylene glycol)-b-poly(γ-propargyl L-glutamate): the substituent effect.

Authors:  Xiaoyong Zhao; Zhiyong Poon; Amanda C Engler; Daniel K Bonner; Paula T Hammond
Journal:  Biomacromolecules       Date:  2012-04-02       Impact factor: 6.988

Review 3.  Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies.

Authors:  Abhirup Mandal; Rohit Bisht; Ilva D Rupenthal; Ashim K Mitra
Journal:  J Control Release       Date:  2017-01-11       Impact factor: 9.776

Review 4.  Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery.

Authors:  Kensuke Osada; R James Christie; Kazunori Kataoka
Journal:  J R Soc Interface       Date:  2009-04-01       Impact factor: 4.118

5.  Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L-aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release.

Authors:  Y Li; G S Kwon
Journal:  Pharm Res       Date:  2000-05       Impact factor: 4.200

Review 6.  The use of ultrasound and micelles in cancer treatment.

Authors:  Ghaleb A Husseini; William G Pitt
Journal:  J Nanosci Nanotechnol       Date:  2008-05

Review 7.  Micelles and nanoparticles for ultrasonic drug and gene delivery.

Authors:  Ghaleb A Husseini; William G Pitt
Journal:  Adv Drug Deliv Rev       Date:  2008-04-04       Impact factor: 15.470

Review 8.  Nanoparticle characterization: state of the art, challenges, and emerging technologies.

Authors:  Eun Jung Cho; Hillary Holback; Karen C Liu; Sara A Abouelmagd; Joonyoung Park; Yoon Yeo
Journal:  Mol Pharm       Date:  2013-03-21       Impact factor: 4.939

9.  Solubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations.

Authors:  Mohanad Naji Sahib; Shaymaa Abdalwahed Abdulameer; Yusrida Darwis; Kok Khiang Peh; Yvonne Tze Fung Tan
Journal:  Drug Des Devel Ther       Date:  2012       Impact factor: 4.162

Review 10.  Development of polymeric micelles for targeting intractable cancers.

Authors:  Nobuhiro Nishiyama; Yasuhiro Matsumura; Kazunori Kataoka
Journal:  Cancer Sci       Date:  2016-06-24       Impact factor: 6.716
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