AIMS: To differentiate the serological profiles of chronic (endocarditis) Q fever from the late follow up of acute cases. METHODS: Twenty patients (10 diagnosed with acute and 10 with endocarditis Q fever) were studied. Those diagnosed with acute infection were followed up from 2.5 to 88 months (mean 35.8 months). Serological variables included indirect immunofluorescence against phase I and II of Coxiella burnetii (IgM, IgG, and IgA), complement fixation and rheumatoid factor (RF). RESULTS: All patients with titres of IgA against phase I, after IgG removal, equal to or above 320 and a complement fixation value equal to or above 128 had endocarditis. No patient with acute Q fever had such a serological profile. CONCLUSIONS: The combination of IgA against phase I and complement fixation values may be sufficient to differentiate the serological profile of chronic (endocarditis) Q fever from the late follow up of acute cases.
AIMS: To differentiate the serological profiles of chronic (endocarditis) Q fever from the late follow up of acute cases. METHODS: Twenty patients (10 diagnosed with acute and 10 with endocarditis Q fever) were studied. Those diagnosed with acute infection were followed up from 2.5 to 88 months (mean 35.8 months). Serological variables included indirect immunofluorescence against phase I and II of Coxiella burnetii (IgM, IgG, and IgA), complement fixation and rheumatoid factor (RF). RESULTS: All patients with titres of IgA against phase I, after IgG removal, equal to or above 320 and a complement fixation value equal to or above 128 had endocarditis. No patient with acute Q fever had such a serological profile. CONCLUSIONS: The combination of IgA against phase I and complement fixation values may be sufficient to differentiate the serological profile of chronic (endocarditis) Q fever from the late follow up of acute cases.
Authors: R C Kimbrough; R A Ormsbee; M Peacock; W R Rogers; R W Bennetts; J Raaf; A Krause; C Gardner Journal: Ann Intern Med Date: 1979-09 Impact factor: 25.391
Authors: M L Fernández-Guerrero; J M Muelas; J M Aguado; G Renedo; J Fraile; F Soriano; E De Villalobos Journal: Ann Intern Med Date: 1988-02 Impact factor: 25.391
Authors: R Gil-Grande; J M Aguado; C Pastor; M García-Bravo; C Gómez-Pellico; F Soriano; A R Noriega Journal: Eur J Clin Microbiol Infect Dis Date: 1995-01 Impact factor: 3.267