| Literature DB >> 8317909 |
M González Barón1, J Feliu, A Ordoñez, A Colmenarejo, E Espinosa, P Zamora, I de la Gandara, J I Jalon.
Abstract
Twenty-six patients with advanced colorectal cancer were treated with UFT and leucovorin (LV). On day 1, patients received LV 500 mg/m2 in IV infusion, followed by 15 mg/12 h for 13 days. On days 1 to 14, patients took oral UFT twice daily. Three cycles were given every 28 days, unless grade III-IV toxicity appeared. The initial dose of UFT (200 mg/day) was increased until 800 mg/day. Dose limiting toxicities were stomatitis, diarrhea and epigastralgia. The maximum tolerated dose of UFT was 390 +/- 10 mg/m2. Three out of 24 evaluable patients achieved a partial response and 1 a complete response with UFT doses of 260 to 390 mg/m2. These results warrant confirmation in phase II studies.Entities:
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Year: 1993 PMID： 8317909
Source DB: PubMed Journal: Anticancer Res ISSN： 0250-7005 Impact factor: 2.480