Literature DB >> 8317415

Mycobacteremia and granulomatous hepatitis following initial intravesical bacillus Calmette-Guerin instillation for bladder carcinoma.

D D Proctor1, S Chopra, S C Rubenstein, J A Jokela, L Uhl.   

Abstract

We describe the first case of mycobacteremia and granulomatous hepatitis occurring after the initial intravesical instillation of bacillus Calmette-Guerin (BCG) for bladder cancer. Eight days after BCG instillation, a liver biopsy revealed well-defined granulomas and acid-fast bacilli. A blood culture drawn 8 h after BCG instillation grew Mycobacterium bovis. We summarize the reported complications of BCG intravesical immunotherapy, the associated risk factors, and discuss options for treatment. Although rare, mycobacteremia and granulomatous hepatitis are important systemic side effects of intravesical instillation of BCG for bladder cancer, and should be considered in any patient who presents with persistent fever and abnormal liver function tests after instillation of BCG.

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Year:  1993        PMID： 8317415

Source DB:  PubMed          Journal:  Am J Gastroenterol        ISSN： 0002-9270            Impact factor:   10.864


  9 in total

1.  Granulomatous hepatitis, choroiditis and aortoduodenal fistula complicating intravesical Bacillus Calmette-Guérin therapy: Case report.

Authors:  Cindy Q Gao; Rozina Mithani; Jack Leya; Lesley Dawravoo; Arvin Bhatia; John Antoine; Felipe De Alba; Peter A Russo; Claus J Fimmel
Journal:  BMC Infect Dis       Date:  2011-09-30       Impact factor: 3.090

2.  Granulomatous hepatitis following intravesical bacillus Calmette-Guerin therapy.

Authors:  B Ozbakkaloglu; O Tünger; S Sürücüoglu; M Lekili; A R Kandiloglu
Journal:  Int Urol Nephrol       Date:  1999       Impact factor: 2.370

3.  Granulomatous hepatitis caused by Bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation.

Authors:  F W Leebeek; R J Ouwendijk; A H Kolk; A Dees; J C Meek; J E Nienhuis; A M Dingemans-Dumas
Journal:  Gut       Date:  1996-04       Impact factor: 23.059

4.  [Sepsis and multiple organ failure after BCG-instillation for bladder cancer].

Authors:  A Elmer; U Bermes; L Drath; E Büscher; A Viertel
Journal:  Internist (Berl)       Date:  2004-08       Impact factor: 0.743

Review 5.  Bacillus Calmette-Guérin (BCG) infection following intravesical BCG administration as adjunctive therapy for bladder cancer: incidence, risk factors, and outcome in a single-institution series and review of the literature.

Authors:  María Asunción Pérez-Jacoiste Asín; Mario Fernández-Ruiz; Francisco López-Medrano; Carlos Lumbreras; Ángel Tejido; Rafael San Juan; Ana Arrebola-Pajares; Manuel Lizasoain; Santiago Prieto; José María Aguado
Journal:  Medicine (Baltimore)       Date:  2014-10       Impact factor: 1.889

6.  An infant with asymptomatic hepatic granuloma probably caused by bacillus Calmette-Guérin (BCG) vaccination found incidentally at autopsy: a case report.

Authors:  Yutaka Tajima; Rie Takagi; Tamiko Nakajima; Yoshihiko Kominato
Journal:  Cases J       Date:  2008-11-20

7.  Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with Bacillus Calmette-Guérin.

Authors:  Aliye Soylu; Ali T Ince; Hakan Polat; Nurgul Yasar; Aydin Ciltas; Selvinaz Ozkara; Ali I Tasci
Journal:  Ann Clin Microbiol Antimicrob       Date:  2009-04-15       Impact factor: 3.944

8.  Acute Hepatitis and Pneumonitis Caused by Disseminated Bacillus Calmette-Guérin Infection.

Authors:  Khaled Dibs; Ihab Shehadeh; Osama Abu Atta
Journal:  ACG Case Rep J       Date:  2016-01-20

9.  Granulomatous hepatitis in a healthy adult after bacillus Calmette-Guérin injection into a plantar wart.

Authors:  Do Sik Moon; Woo Young Choi; Na-Ra Yoon; Dong-Min Kim
Journal:  JAAD Case Rep       Date:  2017-11-08
  9 in total

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