Literature DB >> 8317336

Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.

A M Lefer1, X L Ma, A Weyrich, D J Lefer.   

Abstract

We measured changes in basal release of nitric oxide (NO) and its effect on polymorphonuclear neutrophil (PMN) adherence to endothelial cells (EC) in a feline model of myocardial ischemia and reperfusion (MI/R). Significant reductions in basal NO release occurred 10 minutes following reperfusion, whereas increases in PMN adherence occurred at 20 minutes post-reperfusion. Addition of hSOD blocked the post-reperfusion adherence of PMNs to the endothelium. These results indicate that decreased basal release of NO, following MI/R precedes enhanced PMN adherence to the coronary endothelium, which may lead to PMN-induced myocardial injury.

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Year:  1993        PMID： 8317336

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN： 0379-0363


  17 in total

1.  Dingxin recipe ( ) prevents ischemia/reperfusion-induced arrhythmias via up-regulating prohibitin and suppressing inflammatory responses.

Authors:  Yu-Hua Jia; Yun-Xian Zhang; Li-Jun Li; Ya-Wei Liu; Chun-Hua Li; Xiu-Qiong Fu; Ping Zeng; Wei-Kang Wu; Xue-Gang Sun
Journal:  Chin J Integr Med       Date:  2012-02-05       Impact factor: 1.978

2.  Atheroprotective effects of neuronal nitric oxide synthase in apolipoprotein e knockout mice.

Authors:  Peter J Kuhlencordt; Stefanie Hötten; Johannes Schödel; Sebastian Rützel; Kai Hu; Julian Widder; Alexander Marx; Paul L Huang; Georg Ertl
Journal:  Arterioscler Thromb Vasc Biol       Date:  2006-04-20       Impact factor: 8.311

3.  Pterostilbene attenuates inflammation in rat heart subjected to ischemia-reperfusion: role of TLR4/NF-κB signaling pathway.

Authors:  Chen Wang; Hourong Sun; Yi Song; Zengshan Ma; Gong Zhang; Xinghua Gu; Lei Zhao
Journal:  Int J Clin Exp Med       Date:  2015-02-15

4.  The effect of C1 inhibitor on myocardial ischemia and reperfusion injury.

Authors:  Fengxin Lu; Stacey M Fernandes; Alvin E Davis
Journal:  Cardiovasc Pathol       Date:  2012-06-16       Impact factor: 2.185

5.  Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2/ARE pathway.

Authors:  Liang Cheng; Zhenxiao Jin; Rong Zhao; Kai Ren; Chao Deng; Shiqiang Yu
Journal:  Int J Clin Exp Med       Date:  2015-07-15

6.  Pterostilbene attenuates myocardial ischemia-reperfusion injury via the phosphatidylinositol 3'-kinase-protein kinase B signaling pathway.

Authors:  Lei Hu; Na Cai; Hui Jia
Journal:  Exp Ther Med       Date:  2017-10-02       Impact factor: 2.447

7.  Atorvastatin attenuates inflammation and oxidative stress induced by ischemia/reperfusion in rat heart via the Nrf2 transcription factor.

Authors:  Guoqiang Sun; Yubo Li; Zhiyong Ji
Journal:  Int J Clin Exp Med       Date:  2015-09-15

Review 8.  Postconditioning: a mechanical maneuver that triggers biological and molecular cardioprotective responses to reperfusion.

Authors:  Jakob Vinten-Johansen
Journal:  Heart Fail Rev       Date:  2007-12       Impact factor: 4.214

9.  NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats.

Authors:  Ulrik Wisløff; Russell S Richardson; Alf O Brubakk
Journal:  J Physiol       Date:  2003-01-15       Impact factor: 5.182

Review 10.  Myocardial protection by nitrite.

Authors:  John W Calvert; David J Lefer
Journal:  Cardiovasc Res       Date:  2009-02-27       Impact factor: 10.787
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