Literature DB >> 8317334

A comparison of serotonin (5-HT) blood levels and activity of 5-HT2 antagonists in adjuvant arthritic Lewis and Wistar rats.

M Pertsch1, E Krause, R Hirschelmann.   

Abstract

The total plasma 5-HT levels of adjuvant arthritic rats were increased in animals of both strains in comparison to healthy controls. The exception was day 1, when the 5-HT plasma level in arthritic Lewis rats was decreased by 77%, but only by 17% in Wistar rats. Treatment with the 5-HT2 receptor antagonist ritanserin caused a significant inhibition of macroscopic arthritis at day 14 in Lewis but not in Wistar rats. The total plasma 5-HT level was significantly decreased by the 5-HT2 antagonists in both strains at various times. 5-HT as an autacoid with effects on the T-lymphocytes and on delayed hypersensitivity reactions might be responsible, at least in part, for strain differences regarding the incidence of secondary lesions in rat adjuvant arthritis.

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Year:  1993        PMID： 8317334     DOI： 10.1007/bf01991150

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Initiation of delayed-type hypersensitivity by low doses of monoclonal IgE antibody. Mediation by serotonin and inhibition by histamine.

Authors:  W Ptak; G P Geba; P W Askenase
Journal:  J Immunol       Date:  1991-06-01       Impact factor: 5.422

2.  A new interpretation of the involvement of serotonin in delayed-type hypersensitivity. Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells.

Authors:  J C Ameisen; R Meade; P W Askenase
Journal:  J Immunol       Date:  1989-05-01       Impact factor: 5.422

3.  [Modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and serotonin antagonists, non-steroid antiphlogistics as well as protease inhibitors and their possible relations to inflammation mediators].

Authors:  R Hirschelmann; H Bekemeier; J Metzner; A J Giessler; A Stelzner
Journal:  Acta Biol Med Ger       Date:  1975

4.  Automatic determination of serotonin in biological fluids by liquid chromatography.

Authors:  P Nebinger; M Koel
Journal:  J Chromatogr       Date:  1988-06-03

Review 5.  Modulation of inflammation and immunity by cyclic AMP.

Authors:  H R Bourne; L M Lichtenstein; K L Melmon; C S Henney; Y Weinstein; G M Shearer
Journal:  Science       Date:  1974-04-05       Impact factor: 47.728

6.  The mast cell in early rat adjuvant arthritis.

Authors:  A Gryfe; P M Sanders; D L Gardner
Journal:  Ann Rheum Dis       Date:  1971-01       Impact factor: 19.103

7.  Enhancement of human natural killer cell cytotoxicity by serotonin: role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors.

Authors:  K Hellstrand; S Hermodsson
Journal:  Cell Immunol       Date:  1990-04-15       Impact factor: 4.868

8.  The effects of histamine and serotonin on polymorphonuclear leukocyte accumulation in the rat.

Authors:  J Kheifets; T Thieme; A Mirkovich; N Ackerman
Journal:  Eur J Pharmacol       Date:  1986-09-09       Impact factor: 4.432

9.  Ketanserin reduces a particular monoamine pool in peripheral tissues.

Authors:  J E Leysen; J Wynants; A Eens; P A Janssen
Journal:  Mol Pharmacol       Date:  1989-03       Impact factor: 4.436
  9 in total
  1 in total

1.  Effect of N-Feruloylserotonin and Methotrexate on Severity of Experimental Arthritis and on Messenger RNA Expression of Key Proinflammatory Markers in Liver.

Authors:  Ľudmila Pašková; Viera Kuncírová; Silvester Poništ; Danica Mihálová; Radomír Nosáľ; Juraj Harmatha; Iveta Hrádková; Tomáš Čavojský; František Bilka; Katarína Šišková; Ingrid Paulíková; Lýdia Bezáková; Katarína Bauerová
Journal:  J Immunol Res       Date:  2016-07-31       Impact factor: 4.818
  1 in total

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