Literature DB >> 8317305

Eicosanoid production by the mucosa in inflammatory bowel disease after 5-ASA treatment.

F J Zijlstra1, A P van Dijk, R J Ouwendijk, I C van Riemsdijk-Overbeeke, J H Wilson.   

Abstract

Eicosanoids were measured in biopsies of colonic mucosa from five patients with active ulcerative colitis before and after a four weeks of treatment with 5-amino-salicylic acid (5-ASA). Eicosanoid formation was determined after the addition of 14C-arachidonic acid and stimulation with calcium ionophore A23187. 5-ASA given intra-rectally caused a non-selective suppression of prostanoids, leukotrienes and hydroxy-eicosatetraenoic acids. Changes in arachidonic acid metabolism after 5-ASA treatment were not always reflected in changes in inflammation score.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8317305     DOI： 10.1007/bf01991158

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products.

Authors:  S Tornhamre; C Edenius; G Smedegård; B Sjöquist; J A Lindgren
Journal:  Eur J Pharmacol       Date:  1989-10-10       Impact factor: 4.432

2.  Letter: Prostaglandins, ulcerative colitis, and sulphasalazine.

Authors:  S R Gould
Journal:  Lancet       Date:  1975-11-15       Impact factor: 79.321

3.  Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine.

Authors:  P Sharon; M Ligumsky; D Rachmilewitz; U Zor
Journal:  Gastroenterology       Date:  1978-10       Impact factor: 22.682

4.  Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.

Authors:  J L Wallace; W K MacNaughton; G P Morris; P L Beck
Journal:  Gastroenterology       Date:  1989-01       Impact factor: 22.682

5.  15-HETE is the main eicosanoid formed by human colonic mucosa.

Authors:  F J Zijlstra; A P van Dijk; J H Wilson; I C van Riemsdijk-Overbeeke; J E Vincent; R J Ouwendijk
Journal:  Agents Actions       Date:  1992

6.  Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease.

Authors:  P Sharon; W F Stenson
Journal:  Gastroenterology       Date:  1985-01       Impact factor: 22.682

7.  Selective 5-lipoxygenase inhibition in ulcerative colitis.

Authors:  L S Laursen; J Naesdal; K Bukhave; K Lauritsen; J Rask-Madsen
Journal:  Lancet       Date:  1990-03-24       Impact factor: 79.321

8.  Mechanism of action of 5-arninosalicylic acid.

Authors:  N A Punchard; S M Greenfield; R P Thompson
Journal:  Mediators Inflamm       Date:  1992       Impact factor: 4.711
  8 in total
  3 in total

1.  Effect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa.

Authors:  Andrew P Neilson; Jianwei Ren; Yu H Hong; Ananda Sen; William L Smith; Dean E Brenner; Zora Djuric
Journal:  Nutr Cancer       Date:  2011-12-09       Impact factor: 2.900

2.  Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice.

Authors:  Andrew P Neilson; Zora Djuric; Jianwei Ren; Yu H Hong; Ananda Sen; Corey Lager; Yan Jiang; Shony Reuven; William L Smith; Dean E Brenner
Journal:  J Nutr Biochem       Date:  2011-09-19       Impact factor: 6.048

3.  Intestinal blood flow in murine colitis induced with dextran sulfate sodium.

Authors:  Ingrid M Garrelds; Jan P C Heiligers; Marieke E Van Meeteren; Dirk-Jan G M Duncker; Pramod R Saxena; Maarten A C Meijssen; Frederik J Zijlstra
Journal:  Dig Dis Sci       Date:  2002-10       Impact factor: 3.199
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.