Literature DB >> 8316049

Compounds biologically similar to platelet activating factor are present in stored blood components.

C C Silliman1, C A Johnson, K L Clay, G W Thurman, D R Ambruso.   

Abstract

Agents which prime the neutrophil NADPH oxidase develop during routine storage of whole blood and packed red blood cells. This plasma priming activity can be inhibited by bepafant (WEB 2170), a specific platelet activating factor (PAF) receptor antagonist. Quantitation of the priming agent(s), by a commercially available radioimmunoassay for PAF, reproducibly demonstrated high levels of PAF activity. However, analysis of these plasma samples from stored blood components by gas chromatography/mass spectroscopy did not reveal any 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine. We conclude that the polyclonal antibody to PAF used in these studies may have recognized different epitopes of a family of heterogeneous, biologically active lipids that manifest their effects through the PAF receptor.

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Year:  1993        PMID： 8316049     DOI： 10.1007/bf02535939

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  14 in total

1.  Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor.

Authors:  C C Silliman; G W Thurman; D R Ambruso
Journal:  Vox Sang       Date:  1992       Impact factor: 2.144

2.  A rapid method of total lipid extraction and purification.

Authors:  E G BLIGH; W J DYER
Journal:  Can J Biochem Physiol       Date:  1959-08

3.  Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.

Authors:  H O Heuer; J Casals-Stenzel; G Muacevic; K H Weber
Journal:  J Pharmacol Exp Ther       Date:  1990-12       Impact factor: 4.030

Review 4.  Platelet-activating factor.

Authors:  S M Prescott; G A Zimmerman; T M McIntyre
Journal:  J Biol Chem       Date:  1990-10-15       Impact factor: 5.157

5.  WEB2170, a specific platelet-activating factor antagonist, attenuates neutrophil priming by human serum after clinical burn injury: the 1991 Moyer Award.

Authors:  J M Pitman; G W Thurman; B O Anderson; L L Ketch; C E Hartford; A H Harken; D R Ambruso
Journal:  J Burn Care Rehabil       Date:  1991 Sep-Oct

6.  The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals.

Authors:  L C McPhail; C C Clayton; R Snyderman
Journal:  J Biol Chem       Date:  1984-05-10       Impact factor: 5.157

7.  Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis.

Authors:  M S Caplan; X M Sun; W Hseuh; J R Hageman
Journal:  J Pediatr       Date:  1990-06       Impact factor: 4.406

8.  Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor.

Authors:  D M Stafforini; T M McIntyre; M E Carter; S M Prescott
Journal:  J Biol Chem       Date:  1987-03-25       Impact factor: 5.157

9.  Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor.

Authors:  L M Ingraham; T D Coates; J M Allen; C P Higgins; R L Baehner; L A Boxer
Journal:  Blood       Date:  1982-06       Impact factor: 22.113

10.  Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells.

Authors:  K L Clay; C Johnson; G S Worthen
Journal:  Biochim Biophys Acta       Date:  1991-08-13
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  5 in total

1.  Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial.

Authors:  Jill M Cholette; Kelly F Henrichs; George M Alfieris; Karen S Powers; Richard Phipps; Sherry L Spinelli; Michael Swartz; Francisco Gensini; L Eugene Daugherty; Emily Nazarian; Jeffrey S Rubenstein; Dawn Sweeney; Michael Eaton; Norma B Lerner; Neil Blumberg
Journal:  Pediatr Crit Care Med       Date:  2012-05       Impact factor: 3.624

Review 2.  Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor.

Authors:  Michael A Ellison; Daniel R Ambruso; Christopher C Silliman
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

3.  Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice.

Authors:  Carlton C Barnett; Adam W Beck; Shane E Holloway; Marguerite Kehler; Marie K Schluterman; Rolf A Brekken; Jason B Fleming; Christopher C Silliman
Journal:  Cancer       Date:  2010-08-15       Impact factor: 6.860

4.  Partial characterization of lipids that develop during the routine storage of blood and prime the neutrophil NADPH oxidase.

Authors:  C C Silliman; K L Clay; G W Thurman; C A Johnson; D R Ambruso
Journal:  J Lab Clin Med       Date:  1994-11

Review 5.  The role of neutrophils in the pathogenesis of transfusion-related acute lung injury.

Authors:  Yoke Lin Fung; Christopher C Silliman
Journal:  Transfus Med Rev       Date:  2009-10
  5 in total

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