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Literature DB >> 8315381

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

K H Grabstein¹, T J Waldschmidt, F D Finkelman, B W Hess, A R Alpert, N E Boiani, A E Namen, P J Morrissey.

Abstract

The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations.

Entities: Gene Species

Mesh：

Substances：

Year: 1993 PMID： 8315381 PMCID： PMC2191094 DOI： 10.1084/jem.178.1.257

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

38 in total

1. Regulation of human T cell proliferation by IL-7.

Authors: R J Armitage; A E Namen; H M Sassenfeld; K H Grabstein
Journal: J Immunol Date: 1990-02-01 Impact factor: 5.422

2. Murine thymocytes proliferate in direct response to interleukin-7.

Authors: P J Conlon; P J Morrissey; R P Nordan; K H Grabstein; K S Prickett; S G Reed; R Goodwin; D Cosman; A E Namen
Journal: Blood Date: 1989-09 Impact factor: 22.113

3. Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG.

Authors: F D Finkelman; I Scher; J J Mond; S Kessler; J T Kung; E S Metcalf
Journal: J Immunol Date: 1982-08 Impact factor: 5.422

4. The ontogeny and distribution of B cells in normal and mutant immune-defective CBA/N mice: two-parameter analysis of surface IgM and IgD.

Authors: I Scher; J A Titus; F D Finkelman
Journal: J Immunol Date: 1983-02 Impact factor: 5.422

5. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development.

Authors: R L Coffman
Journal: Immunol Rev Date: 1982 Impact factor: 12.988

6. Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.

Authors: T A Sato; M B Widmer; F D Finkelman; H Madani; C A Jacobs; K H Grabstein; C R Maliszewski
Journal: J Immunol Date: 1993-04-01 Impact factor: 5.422

7. Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny.

Authors: E S Vitetta; U Melcher; M McWilliams; M E Lamm; J M Phillips-Quagliata; J W Uhr
Journal: J Exp Med Date: 1975-01-01 Impact factor: 14.307

8. Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells.

Authors: P J Morrissey; R G Goodwin; R P Nordan; D Anderson; K H Grabstein; D Cosman; J Sims; S Lupton; B Acres; S G Reed
Journal: J Exp Med Date: 1989-03-01 Impact factor: 14.307

9. Interleukin 7 production and function in stromal cell-dependent B cell development.

Authors: T Sudo; M Ito; Y Ogawa; M Iizuka; H Kodama; T Kunisada; S Hayashi; M Ogawa; K Sakai; S Nishikawa
Journal: J Exp Med Date: 1989-07-01 Impact factor: 14.307

10. Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.

Authors: I M Zitron; B L Clevinger
Journal: J Exp Med Date: 1980-11-01 Impact factor: 14.307

99 in total

10. Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.

Authors: Nicholas D Bushar; Evann Corbo; Michelle Schmidt; Jonathan S Maltzman; Donna L Farber
Journal: Proc Natl Acad Sci U S A Date: 2009-12-22 Impact factor: 11.205

Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody.

1. Regulation of human T cell proliferation by IL-7.

2. Murine thymocytes proliferate in direct response to interleukin-7.

3. Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG.

4. The ontogeny and distribution of B cells in normal and mutant immune-defective CBA/N mice: two-parameter analysis of surface IgM and IgD.

5. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development.

6. Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.

7. Cell surface immunoglobulin. XI. The appearance of an IgD-like molecule on murine lymphoid cells during ontogeny.

8. Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells.

9. Interleukin 7 production and function in stromal cell-dependent B cell development.

10. Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.

1. T cell-independent rescue of B lymphocytes from peripheral immune tolerance.

2. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency.

3. Interleukin 7 receptor-deficient mice lack gammadelta T cells.

4. An in vivo IL-7 requirement for peripheral Foxp3+ regulatory T cell homeostasis.

5. A human recombinant IL-7/HGFβ hybrid cytokine enhances antitumor immunity in mice.

6. Myeloid-Derived Suppressor Cells Impair B Cell Responses in Lung Cancer through IL-7 and STAT5.

7. An overview of IL-7 biology and its use in immunotherapy.

Review 8. Transcriptional regulation of early B cell development.

9. Distal-less homeobox transcription factors regulate development and maturation of natural killer cells.

10. Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.