K S Resnik1, E C Vonderheid. 1. Division of Dermatology, Hahnemann University, Philadelphia, PA 19102.
Abstract
BACKGROUND: In 1982 we reported our preliminary observations on the use of home UV phototherapy for patch and early plaque phase mycosis fungoides (MF). OBJECTIVE: Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years. METHODS: All patients used a commercially available UV phototherapy unit that contained four Westinghouse FS40 fluorescent lamps for daily exposures of their non-sun-exposed skin regions. RESULTS: A complete clinical and histologic response to home phototherapy occurred in 23 patients (74%) with a maximum duration of the response from 5 months to more than 15 years (median 51 months). After maintenance phototherapy was discontinued, seven patients (23%) had a sustained disease-free interval lasting more than 58 months (median > 90 months). This indicates that cure may have been achieved in a minority of patients. Phototherapy was well tolerated without evidence of significant photodamage or photocarcinogenicity. CONCLUSION: These observations indicate that home phototherapy may be a therapeutic option for treatment of selected patients with early MF.
BACKGROUND: In 1982 we reported our preliminary observations on the use of home UV phototherapy for patch and early plaque phase mycosis fungoides (MF). OBJECTIVE: Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years. METHODS: All patients used a commercially available UV phototherapy unit that contained four Westinghouse FS40 fluorescent lamps for daily exposures of their non-sun-exposed skin regions. RESULTS: A complete clinical and histologic response to home phototherapy occurred in 23 patients (74%) with a maximum duration of the response from 5 months to more than 15 years (median 51 months). After maintenance phototherapy was discontinued, seven patients (23%) had a sustained disease-free interval lasting more than 58 months (median > 90 months). This indicates that cure may have been achieved in a minority of patients. Phototherapy was well tolerated without evidence of significant photodamage or photocarcinogenicity. CONCLUSION: These observations indicate that home phototherapy may be a therapeutic option for treatment of selected patients with early MF.
Authors: Mayke B G Koek; Vigfús Sigurdsson; Huib van Weelden; Paul H A Steegmans; Carla A F M Bruijnzeel-Koomen; Erik Buskens Journal: BMJ Date: 2010-04-20
Authors: Mayke B G Koek; Erik Buskens; Paul H A Steegmans; Huib van Weelden; Carla A F M Bruijnzeel-Koomen; Vigfús Sigurdsson Journal: BMC Med Res Methodol Date: 2006-08-01 Impact factor: 4.615
Authors: Mayke B G Koek; Erik Buskens; Huib van Weelden; Paul H A Steegmans; Carla A F M Bruijnzeel-Koomen; Vigfús Sigurdsson Journal: BMJ Date: 2009-05-07