Literature DB >> 8314678

The power of systematic genealogical study in familial Alzheimer disease.

A C Bruni1, M P Montesi, I Rainero, L Ferini-Strambi, F Macciardi, L Pinessi, G Gei, D Fragiacomo, L Bergamini.   

Abstract

Several kindreds (N, C, To and RB) with familial Alzheimer disease (FAD) from the same small area of Calabria are currently under study. Recently two of us (F.M. and L.F-S.) identified a family in Milan (FJ01) made up of 3 siblings whose parents were of Calabrian origin. Through a subsequent systematic or blanket genealogical study a link has been traced between kindreds To and FJ01. We discuss the relevance of these results to genetic studies.

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Year:  1993        PMID： 8314678     DOI： 10.1007/bf02335665

Source DB:  PubMed          Journal:  Ital J Neurol Sci        ISSN： 0392-0461


  6 in total

1.  Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

Authors:  P H St George-Hyslop; J L Haines; L A Farrer; R Polinsky; C Van Broeckhoven; A Goate; D R McLachlan; H Orr; A C Bruni; S Sorbi; I Rainero; J F Foncin; D Pollen; J M Cantu; R Tupler; N Voskresenskaya; R Mayeux; J Growden; V A Fried; R H Myers; L Nee; H Backhovens; J J Martin; M Rossor; M J Owen; M Mullan; M E Percy; H Karlinsky; S Rich; L Heston; M Montesi; M Mortilla; N Nacmias; J F Gusella; J A Hardy
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

2.  [Alzheimer's presenile dementia transmitted in an extended kindred].

Authors:  J F Foncin; D Salmon; V Supino-Viterbo; R G Feldman; G Macchi; P Mariotti; C Scoppetta; G Caruso; A C Bruni
Journal:  Rev Neurol (Paris)       Date:  1985       Impact factor: 2.607

3.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

Authors:  P H St George-Hyslop; R E Tanzi; R J Polinsky; J L Haines; L Nee; P C Watkins; R H Myers; R G Feldman; D Pollen; D Drachman
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

4.  Alzheimer's disease: a model from the quantitative study of a large kindred.

Authors:  A C Bruni; M P Montesi; D Salmon; G Gei; J Perre; K H el Hachimi; J F Foncin
Journal:  J Geriatr Psychiatry Neurol       Date:  1992 Jul-Sep       Impact factor: 2.680

Review 5.  Familial Alzheimer's disease: progress and problems.

Authors:  P H St George-Hyslop; R H Myers; J L Haines; L A Farrer; R E Tanzi; K Abe; M F James; P M Conneally; R J Polinsky; J F Gusella
Journal:  Neurobiol Aging       Date:  1989 Sep-Oct       Impact factor: 4.673

6.  Phenotypic heterogeneity in familial Alzheimer's disease: a study of 24 kindreds.

Authors:  T D Bird; S M Sumi; E J Nemens; D Nochlin; G Schellenberg; T H Lampe; A Sadovnick; H Chui; G W Miner; J Tinklenberg
Journal:  Ann Neurol       Date:  1989-01       Impact factor: 11.274
  6 in total
  1 in total

1.  Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation.

Authors:  A C Bruni; L Bernardi; R Colao; E Rubino; N Smirne; F Frangipane; B Terni; S A M Curcio; M Mirabelli; A Clodomiro; R Di Lorenzo; R Maletta; M Anfossi; M Gallo; S Geracitano; C Tomaino; M G Muraca; A Leotta; S G Lio; L Pinessi; I Rainero; S Sorbi; L Nee; G Milan; S Pappatà; A Postiglione; N Abbamondi; G Forloni; P St George Hyslop; E Rogaeva; O Bugiani; G Giaccone; J F Foncin; M G Spillantini; G Puccio
Journal:  Neurology       Date:  2010-02-17       Impact factor: 9.910
  1 in total

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