Literature DB >> 8314064

Effect of ignoring genotype-environment interaction on segregation analysis of quantitative traits.

L Tiret1, L Abel, R Rakotovao.   

Abstract

Thirty replicates of 200 nuclear families (6 members each) were generated under three GxE interaction models. Segregation analyses of these data were performed using a regressive model taking into account an interaction effect or not. Results showed that ignoring the GxE interaction markedly decreased the power for accepting a major gene and led to serious bias in parameter estimates.

Mesh：

Year:  1993        PMID： 8314064     DOI： 10.1002/gepi.1370100642

Source DB:  PubMed          Journal:  Genet Epidemiol        ISSN： 0741-0395            Impact factor:   2.135


  6 in total

Review 1.  Genetics and pulmonary medicine.10: Genetic epidemiology of pulmonary function.

Authors:  Y Chen
Journal:  Thorax       Date:  1999-09       Impact factor: 9.139

2.  Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.

Authors:  Xingguang Luo; Henry R Kranzler; Lingjun Zuo; Shuang Wang; Nicholas J Schork; Joel Gelernter
Journal:  Am J Hum Genet       Date:  2006-04-11       Impact factor: 11.025

3.  Detection of gene-environment interactions in joint segregation and linkage analysis.

Authors:  W J Gauderman; C L Faucett
Journal:  Am J Hum Genet       Date:  1997-11       Impact factor: 11.025

4.  Approximate analysis of QTL-environment interaction with no limits on the number of environments.

Authors:  A B Korol; Y I Ronin; E Nevo
Journal:  Genetics       Date:  1998-04       Impact factor: 4.562

5.  Models of interaction between metabolic genes and environmental exposure in cancer susceptibility.

Authors:  E Taioli; C Zocchetti; S Garte
Journal:  Environ Health Perspect       Date:  1998-02       Impact factor: 9.031

6.  Segregation analysis of non-insulin-dependent diabetes mellitus in Pima Indians: evidence for a major-gene effect.

Authors:  R L Hanson; R C Elston; D J Pettitt; P H Bennett; W C Knowler
Journal:  Am J Hum Genet       Date:  1995-07       Impact factor: 11.025
  6 in total

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