Literature DB >> 8313980

The effect of haloperidol on D2 dopamine receptor subtype mRNA levels in the brain.

C S Fishburn1, C David, S Carmon, S Fuchs.   

Abstract

Chronic neuroleptic treatment induces an increase in the density of D2 dopamine receptors in the striatum. The effect of prolonged administration of haloperidol on mRNA levels of the short (D2S) and long (D2L) isoforms of the D2 dopamine receptor and the D3 dopamine receptor in different brain regions was examined. Haloperidol caused a significant rise in both D2L and D2S mRNA levels in the striatum, but had no effect on D3 mRNA levels. This rise was restricted to the striatum, showing that the effect of haloperidol on dopamine receptor mRNA is both subtype- and tissue-specific.

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Year:  1994        PMID： 8313980     DOI： 10.1016/0014-5793(94)80385-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Brain-derived neurotrophic factor controls dopamine D3 receptor expression: implications for neurodevelopmental psychiatric disorders.

Authors:  Pierre Sokoloff; Olivier Guillin; Jorge Diaz; Patrick Carroll; Nathalie Griffon
Journal:  Neurotox Res       Date:  2002 Nov-Dec       Impact factor: 3.911

2.  Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone.

Authors:  E C Muly; J R Votaw; J Ritchie; L L Howell
Journal:  J Pharmacol Exp Ther       Date:  2012-01-03       Impact factor: 4.030

3.  Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor.

Authors:  C K Hwang; U M D'Souza; A J Eisch; S Yajima; C H Lammers; Y Yang; S H Lee; Y M Kim; E J Nestler; M M Mouradian
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-05       Impact factor: 11.205

4.  Effects of repeated and acute aripiprazole or haloperidol treatment on dopamine synthesis in the dorsal striatum of young rats: comparison to adult rats.

Authors:  Taleen Der-Ghazarian; Sergios Charntikov; Fausto A Varela; Cynthia A Crawford; Sanders A McDougall
Journal:  J Neural Transm (Vienna)       Date:  2010-04-06       Impact factor: 3.575

5.  A paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons.

Authors:  D Lévesque; M P Martres; J Diaz; N Griffon; C H Lammers; P Sokoloff; J C Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

Review 6.  Dopamine and glutamate dysfunctions in schizophrenia: role of the dopamine D3 receptor.

Authors:  L Leriche; J Diaz; P Sokoloff
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

7.  The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Authors:  Edward C Lauterbach; Leonardo F Fontenelle; Antonio L Teixeira
Journal:  Parkinsons Dis       Date:  2011-12-27
  7 in total

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