Literature DB >> 8313838

In vitro methods for assessing human hepatic drug metabolism: their use in drug development.

S A Wrighton1, M Vandenbranden, J C Stevens, L A Shipley, B J Ring, A E Rettie, J R Cashman.   

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Year:  1993        PMID： 8313838     DOI： 10.3109/03602539308993982

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN： 0360-2532            Impact factor:   4.518


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  20 in total

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3.  Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

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Review 4.  The human drug metabolizing cytochromes P450.

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5.  Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions.

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Review 6.  Pharmacokinetics of haloperidol: an update.

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7.  Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.

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8.  Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies.

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9.  The effect of enzyme inhibition on the metabolism and activation of tacrine by human liver microsomes.

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Review 10.  Cytochrome P450 enzyme mediated herbal drug interactions (Part 1).

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