PURPOSE: To verify if the ventricular function and the incidence of arrhythmias in patients of both sexes could be predominant in male patients with Chagas' disease. METHODS: Six hundred and thirty one patients were studied, 329 female and 302 male, with age of 10 to 64 years old (mean 40). All patients were submitted to M mode echocardiographic study to analyse the ejection fraction (EF). To verify the importance of the ventricular dysfunction in male and female patients, they were divided according to the EF in three groups: A) normal EF, B) EF between 0.64 and 0.45 and C) EF less than 0.44. The incidence of ventricular tachycardia was analyzed at the stress test or 24h Holter studies. RESULTS: The number of patients with depressed EF was more frequent on male patients (p < 0.0001). The incidence of ventricular tachycardia was similar in both sexes, however it was more frequent in patients with ventricular dysfunction. CONCLUSION: Our results show that there are greater myocardial dysfunction on male patients, what could explain the worse prognosis observed on patients of this sex.
PURPOSE: To verify if the ventricular function and the incidence of arrhythmias in patients of both sexes could be predominant in male patients with Chagas' disease. METHODS: Six hundred and thirty one patients were studied, 329 female and 302 male, with age of 10 to 64 years old (mean 40). All patients were submitted to M mode echocardiographic study to analyse the ejection fraction (EF). To verify the importance of the ventricular dysfunction in male and female patients, they were divided according to the EF in three groups: A) normal EF, B) EF between 0.64 and 0.45 and C) EF less than 0.44. The incidence of ventricular tachycardia was analyzed at the stress test or 24h Holter studies. RESULTS: The number of patients with depressed EF was more frequent on male patients (p < 0.0001). The incidence of ventricular tachycardia was similar in both sexes, however it was more frequent in patients with ventricular dysfunction. CONCLUSION: Our results show that there are greater myocardial dysfunction on male patients, what could explain the worse prognosis observed on patients of this sex.
Authors: Laíse dos Santos Pereira; Erlane Chaves Freitas; Arduína Sofia Ortet de Barros Vasconcelos Fidalgo; Mônica Coelho Andrade; Darlan da Silva Cândido; José Damião da Silva Filho; Vladimir Michailowsky; Maria de Fátima Oliveira; José Ajax Nogueira Queiroz Journal: Rev Inst Med Trop Sao Paulo Date: 2015 Mar-Apr Impact factor: 1.846
Authors: Grace K Silva; Larissa D Cunha; Catarina V Horta; Alexandre L N Silva; Fredy R S Gutierrez; João S Silva; Dario S Zamboni Journal: PLoS One Date: 2013-02-11 Impact factor: 3.240
Authors: Tiago L M Sanches; Larissa D Cunha; Grace K Silva; Paulo M M Guedes; João Santana Silva; Dario S Zamboni Journal: PLoS One Date: 2014-03-20 Impact factor: 3.240
Authors: Francisca Vorraro; Wafa H K Cabrera; Orlando G Ribeiro; José Ricardo Jensen; Marcelo De Franco; Olga M Ibañez; Nancy Starobinas Journal: Mediators Inflamm Date: 2014-08-13 Impact factor: 4.711