| Literature DB >> 8310460 |
C L Alemán1, R Más, C Hernández, I Rodeiro, E Cerejido, M Noa, A Capote, R Menéndez, A Amor, V Fraga.
Abstract
Policosanol is a natural mixture of higher aliphatic primary alcohols. Oral toxicity of policosanol was evaluated in a 12-month study in which doses from 0.5 to 500 mg/kg were given orally to Sprague Dawley (SD) rats (20/sex/group) daily. There was no treatment-related toxicity. Thus, effects on body weight gain, food consumption, clinical observations, blood biochemistry, hematology, organ weight ratios and histopathological findings were similar in control and treated groups. This study supports the wide safety margin of policosanol when administered chronically.Entities:
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Year: 1994 PMID： 8310460 DOI： 10.1016/0378-4274(94)90147-3
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372