Literature DB >> 8310128

N-acetylcysteine and captopril protect DNA and cells against radiolysis by fast neutrons.

M Spotheim-Maurizot1, F Garnier, C Kieda, R Sabattier, M Charlier.   

Abstract

N-Acetylcysteine and captopril, respectively mucolytic and antihypertensive drugs, contain free sulfhydryl groups. Since in general thiols have well-established radioprotective abilities, we sought putative radioprotective effects of these drugs against therapeutic fast neutrons. We show that pBR322 plasmid DNA is indeed protected against radiolytic strand breakage by both drugs. The oxygen independent protection is consistent with a hydroxyl radical scavenging mechanism. A clonogenicity assay reveals an increase of the survival of SCL-1 cultured keratinocytes irradiated in the presence of the drugs compared with cells irradiated without drugs. Our results suggest possible interferences between treatment with drugs bearing-SH groups and radiotherapy.

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Year:  1993        PMID： 8310128     DOI： 10.1007/BF01225921

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  20 in total

1.  Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities.

Authors:  J L Schwartz; R Mustafi; M A Beckett; E A Czyzewski; E Farhangi; D J Grdina; J Rotmensch; R R Weichselbaum
Journal:  Int J Radiat Biol       Date:  1991-06       Impact factor: 2.694

Review 2.  Protection of DNA by thiols.

Authors:  R C Fahey
Journal:  Pharmacol Ther       Date:  1988       Impact factor: 12.310

3.  The radioprotective effect of N-acetylcysteine in thorax irradiation of mice.

Authors:  L E Blank; J Haveman; N van Zandwijk
Journal:  Radiother Oncol       Date:  1987-09       Impact factor: 6.280

4.  Differential chemoprotection of normal and malignant tissues.

Authors:  J M Yuhas; J B Storer
Journal:  J Natl Cancer Inst       Date:  1969-02       Impact factor: 13.506

5.  Topical use of N-acetylcysteine for reduction of skin reaction to radiation therapy.

Authors:  J A Kim; D G Baker; S S Hahn; N T Goodchild; W C Constable
Journal:  Semin Oncol       Date:  1983-03       Impact factor: 4.929

6.  Direct scavenging of free radicals by captopril, an angiotensin converting enzyme inhibitor.

Authors:  D Bagchi; R Prasad; D K Das
Journal:  Biochem Biophys Res Commun       Date:  1989-01-16       Impact factor: 3.575

7.  Extracellular: intracellular and subcellular concentration gradients of thiols.

Authors:  P Wardman; M F Dennis; M R Stratford; J White
Journal:  Int J Radiat Oncol Biol Phys       Date:  1992       Impact factor: 7.038

Review 8.  Captopril: pharmacology, metabolism and disposition.

Authors:  B H Migdalof; M J Antonaccio; D N McKinstry; S M Singhvi; S J Lan; P Egli; K J Kripalani
Journal:  Drug Metab Rev       Date:  1984       Impact factor: 4.518

9.  Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation.

Authors:  D Murray; A Prager; S C Vanankeren; E M Altschuler; M S Kerr; N H Terry; L Milas
Journal:  Int J Radiat Biol       Date:  1990-07       Impact factor: 2.694

10.  Human keratinocyte membrane lectins: characterization and modulation of their expression by cytokines.

Authors:  D Cerdan; C Grillon; M Monsigny; G Redziniak; C Kieda
Journal:  Biol Cell       Date:  1991       Impact factor: 4.458
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  1 in total

Review 1.  Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight.

Authors:  Mark F McLaughlin; Dorit B Donoviel; Jeffrey A Jones
Journal:  Aerosp Med Hum Perform       Date:  2017-07-01       Impact factor: 1.053
  1 in total

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