Literature DB >> 8310123

Model of mammalian cell reproductive death. I. Basic assumptions and general equations.

G M Obaturov1, V V Moiseenko, A S Filimonov.   

Abstract

A systemic model describing the major radiobiological effects of various types of radiation is proposed. The model base lines were substantiated, and general mathematical equations for cell survival developed. The model takes into consideration such physical and biological factors as linear energy transfer, ion track structure, and structural and functional organization of interphase chromatin. This paper presents the basic assumptions made and general equations for the cell killing.

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Year:  1993        PMID: 8310123     DOI: 10.1007/BF01225916

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN: 0301-634X            Impact factor:   1.925


  22 in total

Review 1.  [Structural-functional organization of DNA in the interphase nucleus. Functional aspects].

Authors:  M V Glazkov
Journal:  Mol Biol (Mosk)       Date:  1988 Mar-Apr

2.  Induction of DNA double-strand breaks by ionizing radiation of different quality and their relevance for cell inactivation.

Authors:  G Kampf
Journal:  Radiobiol Radiother (Berl)       Date:  1988

3.  [Chromosome aberrations and reproductive death of mammalian cells. Quantitative relations between these effects].

Authors:  G M Obaturov; V I Potetnia
Journal:  Radiobiologiia       Date:  1986 Jul-Aug

4.  Relationship between the recovery from sublethal X-ray damage and the rejoining of chromosome breaks in normal human fibroblasts.

Authors:  J S Bedford; M N Cornforth
Journal:  Radiat Res       Date:  1987-09       Impact factor: 2.841

5.  Radiation-induced DNA damage and cellular lethality in cultured mammalian cells.

Authors:  K Sakai; S Okada
Journal:  Radiat Res       Date:  1984-06       Impact factor: 2.841

6.  DNA damage and cell killing. Cause and effect?

Authors:  M M Elkind
Journal:  Cancer       Date:  1985-11-15       Impact factor: 6.860

7.  [Biophysical model of the action of ionizing radiation on DNA].

Authors:  G M Obaturov
Journal:  Radiobiologiia       Date:  1979 Mar-Apr

8.  Cell death, chromosome damage and mitotic delay in normal human, ataxia telangiectasia and retinoblastoma fibroblasts after x-irradiation.

Authors:  F Zampetti-Bosseler; D Scott
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1981-05

9.  Deficient repair of potentially lethal damage in actively growing ataxia telangiectasia cells.

Authors:  H Utsumi; M S Sasaki
Journal:  Radiat Res       Date:  1984-02       Impact factor: 2.841

10.  The nature and repair of DNA lesions that lead to chromosomal aberrations induced by ionizing radiations.

Authors:  A T Natarajan; F Darroudi; L H Mullenders; M Meijers
Journal:  Mutat Res       Date:  1986-05       Impact factor: 2.433

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  1 in total

1.  The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction.

Authors:  David J Brenner
Journal:  Semin Radiat Oncol       Date:  2008-10       Impact factor: 5.934

  1 in total

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