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Literature DB >> 8309991

The potential of protein kinase C as a target for anticancer treatment.

Abstract

Many investigators have embarked upon the search for novel cellular targets for the treatment of cancer. A popular therapeutic strategy is to intervene with the components of cellular signalling systems that are altered during malignancy. The molecular heterogeneity of the protein kinase C (PKC) family and their functional divergence make them attractive targets for anticancer drug development. PKC can also influence the sensitivity of tumor tissue to conventional cytotoxic drugs. As discussed in this review, a complete understanding of the PKC signal transduction pathway is obligatory for the selective destruction of tumor tissue by exploiting PKC as either a target or a modulator of cancer chemotherapeutic agents.

Entities: Disease Gene

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Year: 1993 PMID： 8309991 DOI： 10.1016/0163-7258(93)90070-t

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

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Cited

41 in total

1. 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.

Authors: Thazha P Prakash; Joseph F Johnston; Mark J Graham; Thomas P Condon; Muthiah Manoharan
Journal: Nucleic Acids Res Date: 2004-02-03 Impact factor: 16.971

2. Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.

Authors: C A La Porta; R Comolli
Journal: Clin Exp Metastasis Date: 1997-11 Impact factor: 5.150

3. Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

Authors: Hui He; Alec J Davidson; Daqing Wu; Fray F Marshall; Leland W K Chung; Haiyen E Zhau; Dalin He; Ruoxiang Wang
Journal: Prostate Date: 2010-07-01 Impact factor: 4.104

4. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.

Authors: Samson Amos; Patrick M Martin; Gregory A Polar; Sarah J Parsons; Isa M Hussaini
Journal: J Biol Chem Date: 2004-12-23 Impact factor: 5.157

5. Protein kinases and multidrug resistance.

Authors: M G Rumsby; L Drew; J R Warr
Journal: Cytotechnology Date: 1998-09 Impact factor: 2.058

6. Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.

Authors: Alakananda Basu; Savitha Sridharan; Shalini Persaud
Journal: Cell Signal Date: 2009-07-23 Impact factor: 4.315

The potential of protein kinase C as a target for anticancer treatment.

1. 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.

2. Activation of protein kinase C-alpha isoform in murine melanoma cells with high metastatic potential.

3. Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

4. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells.

5. Protein kinases and multidrug resistance.

6. Regulation of protein kinase C delta downregulation by protein kinase C epsilon and mammalian target of rapamycin complex 2.

7. Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response element.

8. Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance.

9. In vivo and in vitro phosphorylation of annexin II in T cells: potential regulation by annexin V.

10. PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1.