Literature DB >> 830858

Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds.

J R Piper, J A Montgomery.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 830858     DOI： 10.1021/jo00422a005

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


× No keyword cloud information.
  4 in total

1.  gamma-Fluoromethotrexate: synthesis and biological activity of a potent inhibitor of dihydrofolate reductase with greatly diminished ability to form poly-gamma-glutamates.

Authors:  J Galivan; J Inglese; J J McGuire; Z Nimec; J K Coward
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter.

Authors:  Alan Menter; Breck Thrash; Christina Cherian; Larry H Matherly; Lei Wang; Aleem Gangjee; Joel R Morgan; Dean Y Maeda; Aaron D Schuler; Stuart J Kahn; John A Zebala
Journal:  J Pharmacol Exp Ther       Date:  2012-05-31       Impact factor: 4.030

3.  Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.

Authors:  Ying Zhao; William R Shadrick; Miranda J Wallace; Yinan Wu; Elizabeth C Griffith; Jianjun Qi; Mi-Kyung Yun; Stephen W White; Richard E Lee
Journal:  Bioorg Med Chem Lett       Date:  2016-07-04       Impact factor: 2.823

4.  Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.

Authors:  Antonio Cavazzuti; Giuseppe Paglietti; William N Hunter; Francisco Gamarro; Sandra Piras; Mario Loriga; Sergio Allecca; Paola Corona; Karen McLuskey; Lindsay Tulloch; Federica Gibellini; Stefania Ferrari; Maria Paola Costi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-01       Impact factor: 11.205
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.