Literature DB >> 8307581

Regional mapping of short tandem repeats on human chromosome 10: cytochrome P450 gene CYP2E, D10S196, D10S220, and D10S225.

K Kölble1.   

Abstract

Human CYP2E encodes an ethanol-inducible cytochrome P450 monooxygenase that metabolizes various carcinogens and may therefore play a role in cancer susceptibility. An intronic (GGAT)n.(CCTA)n repeat element was found to display limited polymorphism in Caucasoids and was used as a sequence-tagged site for genomic amplification from somatic cell hybrids to localize CYP2E to 10q24.3-qter; using the same panel, three microsatellite markers, D10S196, D10S220, and D10S225, were mapped to 10q21. The close synteny of CYP2E, CYP2C, and CYP17 belonging to two different cytochrome P450 families suggests a central role for the long arm of chromosome 10 in the evolution of this large gene superfamily.

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Year:  1993        PMID： 8307581     DOI： 10.1016/s0888-7543(05)80378-7

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  6 in total

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Authors:  Jinchuan Xing; Tana Wuren; Tatum S Simonson; W Scott Watkins; David J Witherspoon; Wilfred Wu; Ga Qin; Chad D Huff; Lynn B Jorde; Ri-Li Ge
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  6 in total

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