Literature DB >> 8307580

The gene for murine CTP:phosphocholine cytidylyltransferase (Ctpct) is located on mouse chromosome 16.

M S Rutherford1, C O Rock, N A Jenkins, D J Gilbert, T G Tessner, N G Copeland, S Jackowski.   

Abstract

CTP:phosphocholine cytidylyltransferase is the rate-controlling enzyme in phosphatidylcholine biosynthesis and is essential for the survival of eukaryotic cells. The murine cDNA for the cytidylyltransferase was cloned and sequenced. A genomic clone was isolated and the chromosomal location of the Ctpct locus determined by Southern blot hybridization of DNAs from a panel of interspecific backcross progeny derived from matings of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice. These data place the Ctpct gene on mouse chromosome 16 between the Smst and Stf-1 genes.

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Year:  1993        PMID： 8307580     DOI： 10.1016/s0888-7543(05)80377-5

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  2 in total

1.  Expression of phosphatidylethanolamine N-methyltransferase-2 in McArdle-RH7777 hepatoma cells inhibits the CDP-choline pathway for phosphatidylcholine biosynthesis via decreased gene expression of CTP:phosphocholine cytidylyltransferase.

Authors:  Z Cui; M Houweling; D E Vance
Journal:  Biochem J       Date:  1995-12-15       Impact factor: 3.857

2.  Functions of the C-terminal domain of CTP: phosphocholine cytidylyltransferase. Effects of C-terminal deletions on enzyme activity, intracellular localization and phosphorylation potential.

Authors:  R B Cornell; G B Kalmar; R J Kay; M A Johnson; J S Sanghera; S L Pelech
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857
  2 in total

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