Literature DB >> 8307195

Effects of calcium ions on proteolytic processing of HIV-1 gp160 precursor and on cell fusion.

M Moulard1, L Montagnier, E Bahraoui.   

Abstract

Complete activation of human immunodeficiency virus type 1 (HIV-1) requires the endoproteolytic cleavage by cellular protease of the envelope glycoprotein precursor (gp160) into the external glycoprotein gp120, and the transmembrane glycoprotein gp41. We report here the effect of depletion of cellular calcium ions on maturation of precursor gp160 and its concomitant effect on syncytium formation. We show that the cellular endoprotease activity responsible for gp160 maturation and the capacity for HIV-1 to induce syncytium formation are calcium-dependent. In addition, we show that endoproteolytic maturation is a key step in syncytium formation induced by HIV-1.

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Year:  1994        PMID： 8307195     DOI： 10.1016/0014-5793(94)80284-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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2.  Specific in vitro cleavage of a Leishmania virus capsid-RNA-dependent RNA polymerase polyprotein by a host cysteine-like protease.

Authors:  Y T Ro; S M Scheffter; J L Patterson
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

3.  Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.

Authors:  F Vollenweider; S Benjannet; E Decroly; D Savaria; C Lazure; G Thomas; M Chrétien; N G Seidah
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

4.  Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes.

Authors:  L Miranda; J Wolf; S Pichuantes; R Duke; A Franzusoff
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

5.  Effect of alpha-1 antitrypsin Portland variant (alpha 1-PDX) on HIV-1 replication.

Authors:  B Bahbouhi; M Bendjennat; D Guétard; N G Seidah; E Bahraoui
Journal:  Biochem J       Date:  2000-11-15       Impact factor: 3.857

6.  Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription.

Authors:  Catherine DeMarino; Maria Cowen; Pooja Khatkar; Bianca Cotto; Heather Branscome; Yuriy Kim; Sarah Al Sharif; Emmanuel T Agbottah; Weidong Zhou; Cecilia T Costiniuk; Mohammad-Ali Jenabian; Cohava Gelber; Lance A Liotta; Dianne Langford; Fatah Kashanchi
Journal:  Cells       Date:  2022-02-18       Impact factor: 6.600

7.  Subcellular localization and calcium and pH requirements for proteolytic processing of the Hendra virus fusion protein.

Authors:  Cara Theresia Pager; Mark Allen Wurth; Rebecca Ellis Dutch
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

8.  Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing.

Authors:  Zhitao Wan; Yimei Lu; Qingjiao Liao; Yang Wu; Xulin Chen
Journal:  PLoS One       Date:  2012-06-13       Impact factor: 3.240
  8 in total

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