Literature DB >> 8307175

A novel gene delivery system using EGF receptor-mediated endocytosis.

J Chen1, S Gamou, A Takayanagi, N Shimizu.   

Abstract

A monoclonal antibody to the human epidermal growth factor (EGF) receptor was conjugated with polylysine and the resulting conjugate was affinity-linked with DNA (gene). This novel gene delivery system utilizes receptor-mediated endocytosis and would be especially suitable for gene therapy for EGF receptor-overproducing squamous cell carcinomas.

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Year:  1994        PMID： 8307175     DOI： 10.1016/0014-5793(94)80357-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

Review 1.  Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution.

Authors:  Y Takakura; M Hashida
Journal:  Pharm Res       Date:  1996-06       Impact factor: 4.200

2.  In vivo gene delivery to the liver using novel galactosylated cationic liposomes.

Authors:  S Kawakami; S Fumoto; M Nishikawa; F Yamashita; M Hashida
Journal:  Pharm Res       Date:  2000-03       Impact factor: 4.200

Review 3.  Amphotropic but not atherotropic: another caveat for adenoviral gene therapy.

Authors:  W Casscells; J T Willerson
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

4.  Effects of cellular pharmacology on drug distribution in tissues.

Authors:  R K Rippley; C L Stokes
Journal:  Biophys J       Date:  1995-09       Impact factor: 4.033

5.  Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems.

Authors:  Ahmed A Abdellatif; Jennifer L Pelt; Richard L Benton; Russell M Howard; Pantelis Tsoulfas; Peipei Ping; Xiao-Ming Xu; Scott R Whittemore
Journal:  J Neurosci Res       Date:  2006-08-15       Impact factor: 4.164

Review 6.  Cationic polymer based gene delivery systems.

Authors:  S C De Smedt; J Demeester; W E Hennink
Journal:  Pharm Res       Date:  2000-02       Impact factor: 4.200

7.  Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor.

Authors:  Yi Wang; Jiliang Wu; Zhixiang Wang
Journal:  Mol Biol Cell       Date:  2006-03-08       Impact factor: 4.138

Review 8.  Nanotechnology: intelligent design to treat complex disease.

Authors:  Patrick Couvreur; Christine Vauthier
Journal:  Pharm Res       Date:  2006-06-21       Impact factor: 4.580

Review 9.  Cell and tissue targeting of nucleic acids for cancer gene therapy.

Authors:  Verena Russ; Ernst Wagner
Journal:  Pharm Res       Date:  2007-03-27       Impact factor: 4.580

10.  Targeting the EGF receptor for ovarian cancer therapy.

Authors:  Reema Zeineldin; Carolyn Y Muller; M Sharon Stack; Laurie G Hudson
Journal:  J Oncol       Date:  2009-12-28       Impact factor: 4.375
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