Literature DB >> 8307148

Cloning and functional expression of a cardiac inward rectifier K+ channel.

K Ishii1, T Yamagishi, N Taira.   

Abstract

We have isolated a cDNA coding for an inward rectifier K+ channel (RBHIK1) from rabbit heart. The cloned cDNA encodes a protein of 427 amino acids with two putative transmembrane segments. The primary structure of RBHIK1 is highly homologous to that of IRK1 which is an inward rectifier K+ channel recently cloned from mouse macrophage by expression cloning. When expressed in Xenopus oocytes, RBHIK1 current showed strong inward rectification and was inhibited by extracellular Ba2+ and Cs+. RNA blot analysis revealed the expression of RBHIK1 mRNA in various rabbit tissues, especially high level in the ventricular muscle.

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Year:  1994        PMID： 8307148     DOI： 10.1016/0014-5793(94)80126-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2.

Authors:  Carsten Zobel; Hee Cheol Cho; The-Tin Nguyen; Roman Pekhletski; Roberto J Diaz; Gregory J Wilson; Peter H Backx
Journal:  J Physiol       Date:  2003-06-06       Impact factor: 5.182

2.  IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.

Authors:  C Karschin; E Dissmann; W Stühmer; A Karschin
Journal:  J Neurosci       Date:  1996-06-01       Impact factor: 6.167

3.  Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity.

Authors:  Gernot Schram; Peter Melnyk; Marc Pourrier; Zhiguo Wang; Stanley Nattel
Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

4.  Mechanisms for the time-dependent decay of inward currents through cloned Kir2.1 channels expressed in Xenopus oocytes.

Authors:  R C Shieh
Journal:  J Physiol       Date:  2000-07-15       Impact factor: 5.182

5.  Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes.

Authors:  G X Liu; C Derst; G Schlichthörl; S Heinen; G Seebohm; A Brüggemann; W Kummer; R W Veh; J Daut; R Preisig-Müller
Journal:  J Physiol       Date:  2001-04-01       Impact factor: 5.182

Review 6.  Phosphoinositide-mediated gating of inwardly rectifying K(+) channels.

Authors:  Diomedes E Logothetis; Taihao Jin; Dmitry Lupyan; Avia Rosenhouse-Dantsker
Journal:  Pflugers Arch       Date:  2007-05-23       Impact factor: 3.657

Review 7.  Cholesterol and Kir channels.

Authors:  Irena Levitan
Journal:  IUBMB Life       Date:  2009-08       Impact factor: 3.885

8.  In vivo expression of a light-activatable potassium channel using unnatural amino acids.

Authors:  Ji-Yong Kang; Daichi Kawaguchi; Irene Coin; Zheng Xiang; Dennis D M O'Leary; Paul A Slesinger; Lei Wang
Journal:  Neuron       Date:  2013-10-16       Impact factor: 17.173
  8 in total

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