Literature DB >> 8307146

Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization.

T Coppola1, R Waldmann, M Borsotto, C Heurteaux, G Romey, M G Mattéi, M Lazdunski.   

Abstract

A cDNA encoding a N-type Ca2+ channel has been cloned from the murine neuroblastoma cell line N1A103. The open reading frame encodes a protein of 2,289 amino acids (257 kDa). Analysis of different clones provided evidence for the existence of distinct isoforms of N-type channels. High levels of mRNA were found in the pyramidal cell layers CA1, CA2 and CA3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 and 4, in the subiculum and the habenula. The N-type Ca2+ channel gene has been localized on the chromosome 2, band A.

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Year:  1994        PMID： 8307146     DOI： 10.1016/0014-5793(94)80105-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Control of gating mode by a single amino acid residue in transmembrane segment IS3 of the N-type Ca2+ channel.

Authors:  H Zhong; B Li; T Scheuer; W A Catterall
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

2.  Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons.

Authors:  Z Lin; Y Lin; S Schorge; J Q Pan; M Beierlein; D Lipscombe
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

3.  Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.

Authors:  J Q Pan; D Lipscombe
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

4.  Coexpression of cloned alpha(1B), beta(2a), and alpha(2)/delta subunits produces non-inactivating calcium currents similar to those found in bovine chromaffin cells.

Authors:  A L Cahill; J H Hurley; A P Fox
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

Review 5.  Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1.

Authors:  Diane Lipscombe; Jennifer Qian Pan; Annette C Gray
Journal:  Mol Neurobiol       Date:  2002-08       Impact factor: 5.590

6.  Identification and characterization of novel human Ca(v)2.2 (alpha 1B) calcium channel variants lacking the synaptic protein interaction site.

Authors:  Shuji Kaneko; Conan B Cooper; Naoto Nishioka; Hironobu Yamasaki; Atsushi Suzuki; Scott E Jarvis; Akinori Akaike; Masamichi Satoh; Gerald W Zamponi
Journal:  J Neurosci       Date:  2002-01-01       Impact factor: 6.167

Review 7.  Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.

Authors:  E Sher; P Rosa; M Francolini; A Codignola; E Morlacchi; E Taverna; F Giovannini; A Brioschi; F Clementi; M W McEnery; M Passafaro
Journal:  J Bioenerg Biomembr       Date:  1998-08       Impact factor: 2.945

8.  Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

Authors:  M Ino; T Yoshinaga; M Wakamori; N Miyamoto; E Takahashi; J Sonoda; T Kagaya; T Oki; T Nagasu; Y Nishizawa; I Tanaka; K Imoto; S Aizawa; S Koch; A Schwartz; T Niidome; K Sawada; Y Mori
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

Review 9.  Control of neuronal voltage-gated calcium ion channels from RNA to protein.

Authors:  Diane Lipscombe; Summer E Allen; Cecilia P Toro
Journal:  Trends Neurosci       Date:  2013-07-30       Impact factor: 13.837

10.  Alternative splicing in the synaptic protein interaction site of rat Ca(v)2.2 (alpha (1B)) calcium channels: changes induced by chronic inflammatory pain.

Authors:  Sareh Asadi; Mohammad Javan; Abolhassan Ahmadiani; Mohammad Hossein Sanati
Journal:  J Mol Neurosci       Date:  2009-01-06       Impact factor: 3.444
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