Literature DB >> 8306538

Chemotherapy of malaria: a battle against all odds?

H H van Es1, E Skamene, E Schurr.   

Abstract

The most important treatment of malaria to date is chemotherapy using a number of different natural and synthetic drugs. Antifolates, such as pyrimethamine, inhibit the parasite's dihydrofolatereductase, whereas the aminoquinolines, such as chloroquine, have the digestive vacuole as their major site of action. The use of these drugs in chemotherapy of malaria infections is strongly hampered by widespread resistance and in this review current knowledge on the molecular mechanisms of resistance is discussed. Finally, new antimalarial drugs and treatment strategies are considered which may offer new possibilities for the treatment of malaria resistant to the drugs currently in use.

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Year:  1993        PMID： 8306538

Source DB:  PubMed          Journal:  Clin Invest Med        ISSN： 0147-958X            Impact factor:   0.825


  5 in total

1.  Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

Authors:  R G Ridley; H Matile; C Jaquet; A Dorn; W Hofheinz; W Leupin; R Masciadri; F P Theil; W F Richter; M A Girometta; A Guenzi; H Urwyler; E Gocke; J M Potthast; M Csato; A Thomas; W Peters
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

2.  4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum.

Authors:  R G Ridley; W Hofheinz; H Matile; C Jaquet; A Dorn; R Masciadri; S Jolidon; W F Richter; A Guenzi; M A Girometta; H Urwyler; W Huber; S Thaithong; W Peters
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

3.  Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine.

Authors:  H H van Es; S Karcz; F Chu; A F Cowman; S Vidal; P Gros; E Schurr
Journal:  Mol Cell Biol       Date:  1994-04       Impact factor: 4.272

4.  Quinine specifically inhibits the proteolipid subunit of the F0F1 H+ -ATPase of Streptococcus pneumoniae.

Authors:  R Muñoz; E García; A G De la Campa
Journal:  J Bacteriol       Date:  1996-04       Impact factor: 3.490

5.  Plasmodium falciparum: Assessment of Selectivity of Action of Chloroquine, Alchornea cordifolia, Ficus polita, and Other Drugs by a Tetrazolium-Based Colorimetric Assay.

Authors:  Nana Kofi Ayisi; Regina Appiah-Opong; Ben Gyan; Kwasi Bugyei; Fred Ekuban
Journal:  Malar Res Treat       Date:  2011-12-01
  5 in total

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