| Literature DB >> 8306145 |
D P Sandhu1, K W Munson, J S Harrop, M R Hopton, W A Ratcliffe.
Abstract
Parathyroid hormone related protein (PTHRP) has been implicated in humoral hypercalcaemia of malignancy (HHM). We describe a patient with a renal carcinoma and hypercalcaemia, and for the first time have demonstrated a 4-fold PTHRP concentration gradient across a renal tumour bed. This provides further strong evidence that the primary tumour was the source of the PTHRP. The PTHRP 1-86 content of the tumour tissue was 4.8 ng/g, similar to that previously found in tumours associated with HHM. In PTHRP-secreting tumours, PTHRP may be a useful oncological marker after surgical resection.Entities:
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Year: 1993 PMID： 8306145 DOI： 10.1111/j.1464-410x.1993.tb16285.x
Source DB: PubMed Journal: Br J Urol ISSN： 0007-1331