Literature DB >> 8306064

Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells.

G Edwards1, A H Weston.   

Abstract

In insulinoma cells (RINm5F), the glibenclamide-sensitive K-current (IK(ATP)) which developed spontaneously or after exposure to levcromakalim or to butanedione monoxime was always accompanied by a reduction in the delayed rectifier current (IK(V)). At potentials over which IK(V) was fully activated, the total outward current remained constant. In rat portal vein, the delayed rectifier channel inhibitor, margatoxin, reduced the combined induction of IK(ATP) and inhibition of IK(V) by levcromakalim. These data suggest that the ATP-sensitive K-channel, K(ATP), is a voltage-insensitive state of the delayed rectifier, KV.

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Year:  1993        PMID： 8306064      PMCID： PMC2175876          DOI： 10.1111/j.1476-5381.1993.tb13955.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Levcromakalim may induce a voltage-independent K-current in rat portal veins by modifying the gating properties of the delayed rectifier.

Authors:  G Edwards; T Ibbotson; A H Weston
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

2.  Effects of P1060 and aprikalim on whole-cell currents in rat portal vein; inhibition by glibenclamide and phentolamine.

Authors:  T Ibbotson; G Edwards; T Noack; A H Weston
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

3.  Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.

Authors:  M Garcia-Calvo; R J Leonard; J Novick; S P Stevens; W Schmalhofer; G J Kaczorowski; M L Garcia
Journal:  J Biol Chem       Date:  1993-09-05       Impact factor: 5.157

4.  Phosphate and thiophosphate group donating adenine and guanine nucleotides inhibit glibenclamide binding to membranes from pancreatic islets.

Authors:  M Schwanstecher; S Löser; I Rietze; U Panten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-01       Impact factor: 3.000

5.  Properties of diazoxide and cromakalim-induced activation of potassium channels in cultured rat and RINm5F insulin-secreting cells; effects of GTP.

Authors:  E A Harding; J H Jaggar; B J Ayton; M J Dunne
Journal:  Exp Physiol       Date:  1993-01       Impact factor: 2.969

6.  Single channel and whole-cell K-currents evoked by levcromakalim in smooth muscle cells from the rabbit portal vein.

Authors:  D J Beech; H Zhang; K Nakao; T B Bolton
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739
  6 in total
  7 in total

1.  Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

Authors:  Tonghui Ma; Jay R Thiagarajah; Hong Yang; Nitin D Sonawane; Chiara Folli; Luis J V Galietta; A S Verkman
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

Review 2.  Pharmacology of the potassium channel openers.

Authors:  G Edwards; A H Weston
Journal:  Cardiovasc Drugs Ther       Date:  1995-03       Impact factor: 3.727

3.  Inhibition of delayed rectifier K(+)-current by levcromakalim in single intestinal smooth muscle cells: effects of cations and dependence on K(+)-flux.

Authors:  D McHugh; D J Beech
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

4.  Tolbutamide causes open channel blockade of cystic fibrosis transmembrane conductance regulator Cl- channels.

Authors:  C J Venglarik; B D Schultz; A D DeRoos; A K Singh; R J Bridges
Journal:  Biophys J       Date:  1996-06       Impact factor: 4.033

Review 5.  Redox control of cardiac excitability.

Authors:  Nitin T Aggarwal; Jonathan C Makielski
Journal:  Antioxid Redox Signal       Date:  2012-08-16       Impact factor: 8.401

6.  Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.

Authors:  Germain Sotoing Taïwe; Elisabeth Ngo Bum; Emmanuel Talla; Théophile Dimo; Norbert Weiss; Neteydji Sidiki; Amadou Dawe; Fleur Clarisse Okomolo Moto; Paul Désiré Dzeufiet; Michel De Waard
Journal:  Pharm Biol       Date:  2010-09-07       Impact factor: 3.503

7.  Potentiation of P1075-induced K+ channel opening by stimulation of adenylate cyclase in rat isolated aorta.

Authors:  C Linde; U Quast
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739
  7 in total

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