Literature DB >> 8305900

Functional relevance of presynaptic muscarinic autoreceptors.

H Kilbinger1, C Dietrich, R S von Bardeleben.   

Abstract

Pre- and postsynaptic muscarinic receptors have been characterized in the isolated trachea and ileal circular muscle of the guinea pig. The muscarinic autoreceptors mediating inhibition of acetylcholine release in the circular muscle belong to the M1 subtype, whereas those inhibiting acetylcholine release in the trachea are M2 or M4 receptors. In both tissues the postsynaptic muscarinic receptors are M3 receptors. Blockade of the autoreceptors by selective M1 and M2/M4 receptor antagonists leads to facilitation of cholinergic neurotransmission.

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Year:  1993        PMID： 8305900     DOI： 10.1016/0928-4257(93)90001-a

Source DB:  PubMed          Journal:  J Physiol Paris        ISSN： 0928-4257


  4 in total

1.  An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338.

Authors:  Yumiko Kanemoto; Hitoshi Ishibashi; Atsushi Doi; Norio Akaike; Yushi Ito
Journal:  Br J Pharmacol       Date:  2002-03       Impact factor: 8.739

2.  Muscarinic inhibition of endogenous noradrenaline release from rabbit isolated trachea: receptor subtype and receptor reserve.

Authors:  C Hey; I Wessler; K Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

3.  Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms.

Authors:  Becky J Proskocil; Donald A Bruun; Charles M Thompson; Allison D Fryer; Pamela J Lein
Journal:  PLoS One       Date:  2010-05-10       Impact factor: 3.240

4.  Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum.

Authors:  C Dietrich; H Kilbinger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-03       Impact factor: 3.000
  4 in total

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