Literature DB >> 8303096

Melatonin receptors in purified cell nuclei of liver.

D Acuña-Castroviejo1, M I Pablos, A Menendez-Pelaez, R J Reiter.   

Abstract

Specific binding of [125I]iodomelatonin to homogenates from purified rat liver nuclei was characterized. The binding is rapid, reversible, saturable and of high affinity. Specific binding seems to be found in the nuclear protein fraction, since after precipitation of the proteins with trichloroacetic acid, the specific binding disappeared. The Kd (180 +/- 20 pM) and Bmax (9.1 +/- 0.03 fmol/mg protein) values (mean +/- S.E.M.) agree with the melatonin concentration in nuclei and may imply a physiological locus for melatonin action.

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Year:  1993        PMID： 8303096

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  6 in total

Review 1.  Melatonin transport into mitochondria.

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Journal:  Cell Mol Life Sci       Date:  2017-08-21       Impact factor: 9.261

Review 2.  The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases.

Authors:  Paula Aranda-Martínez; José Fernández-Martínez; Yolanda Ramírez-Casas; Ana Guerra-Librero; César Rodríguez-Santana; Germaine Escames; Darío Acuña-Castroviejo
Journal:  Int J Mol Sci       Date:  2022-07-04       Impact factor: 6.208

Review 3.  Extrapineal melatonin: sources, regulation, and potential functions.

Authors:  Darío Acuña-Castroviejo; Germaine Escames; Carmen Venegas; María E Díaz-Casado; Elena Lima-Cabello; Luis C López; Sergio Rosales-Corral; Dun-Xian Tan; Russel J Reiter
Journal:  Cell Mol Life Sci       Date:  2014-02-20       Impact factor: 9.261

4.  Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand.

Authors:  I Wiesenberg; M Missbach; J P Kahlen; M Schräder; C Carlberg
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971

Review 5.  ROR: Nuclear Receptor for Melatonin or Not?

Authors:  Haozhen Ma; Jun Kang; Wenguo Fan; Hongwen He; Fang Huang
Journal:  Molecules       Date:  2021-05-04       Impact factor: 4.411

6.  Melatonin: bone metabolism in oral cavity.

Authors:  Fanny López-Martínez; Patricia N Olivares Ponce; Miriam Guerra Rodríguez; Ricardo Martínez Pedraza
Journal:  Int J Dent       Date:  2012-08-09
  6 in total

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