| Literature DB >> 8301454 |
E G John1, L C Fornell, J Radhakrishnan, S Anutrakulchai, O Jonasson.
Abstract
Cyclosporin A has markedly improved graft survival in transplant patients but its side effects, such as renal toxicity and hypertension, pose management problems in transplant recipients. This toxicity has been attributed to prostaglandin inhibition. Concurrent administration of misoprostol (a prostaglandin E1 analog) prevents chronic cyclosporin A-induced nephrotoxicity but not hypertension in rats.Entities:
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Year: 1993 PMID： 8301454 DOI： 10.1016/0022-3468(93)90425-k
Source DB: PubMed Journal: J Pediatr Surg ISSN： 0022-3468 Impact factor: 2.545