Literature DB >> 8300691

Perioperative prophylactic cephazolin in spinal surgery. A double-blind placebo-controlled trial.

E Rubinstein1, G Findler, P Amit, I Shaked.   

Abstract

We investigated the efficacy of a single dose of 1 g of cephazolin in reducing postoperative infections in patients undergoing 'clean' operations on the lumbar spine. In a double-blind, randomised, trial there were 21 wound or urinary infections in the 71 patients who received placebo and nine in the 70 who received cephazolin (p < 0.05). Nine of the placebo patients (12.7%) developed wound infections (complicated by bacteraemia in two) compared with three (4.3%) in the cephazolin group (p = 0.07). Hospital stay was longer for infected patients than for non-infected patients (p < 0.05). Cephazolin-resistant pathogens were isolated more frequently from patients who received cephazolin than from those who received placebo.

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Year:  1994        PMID： 8300691

Source DB:  PubMed          Journal:  J Bone Joint Surg Br        ISSN： 0301-620X


  16 in total

1.  Comparison of Serum CRP and Procalcitonin in Patients after Spine Surgery.

Authors:  Yeon Gu Chung; Yu Sam Won; Young Joon Kwon; Hyun Chul Shin; Chun Sik Choi; Joon-Sup Yeom
Journal:  J Korean Neurosurg Soc       Date:  2011-01-31

Review 2.  Postoperative spinal wound infections and postprocedural diskitis.

Authors:  Saad B Chaudhary; Michael J Vives; Sushil K Basra; Mitchell F Reiter
Journal:  J Spinal Cord Med       Date:  2007       Impact factor: 1.985

3.  Surgical site infection in spinal surgery: a comparative study between 2-octyl-cyanoacrylate and staples for wound closure.

Authors:  Muneharu Ando; Tetsuya Tamaki; Munehito Yoshida; Shunji Sasaki; Yasushi Toge; Takuji Matsumoto; Kazuhiro Maio; Ryosuke Sakata; Daisuke Fukui; Seiji Kanno; Yukihiro Nakagawa; Hiroshi Yamada
Journal:  Eur Spine J       Date:  2014-02-01       Impact factor: 3.134

4.  Surgical Site Infections after Spinal Surgery in a Tropical Area: A Prospective Monocentric Observational Study.

Authors:  Mathieu Severyns; François-Xavier Hostalrich; Laure Flurin; Tanguy Vendeuvre; Arnaud Germaneau; Jean-Marie Turmel; André Cabié; Abdelkrim Benchikh El-Fegoun
Journal:  Am J Trop Med Hyg       Date:  2022-06-27       Impact factor: 3.707

5.  Anterior cervical discectomy with fusion in patients with cervical disc degeneration: a prospective outcome study of 258 patients (181 fused with autologous bone graft and 77 fused with a PEEK cage).

Authors:  Bjarne Lied; Paal Andre Roenning; Jarle Sundseth; Eirik Helseth
Journal:  BMC Surg       Date:  2010-03-21       Impact factor: 2.102

6.  Antimicrobial prophylaxis to prevent surgical site infection in adolescent idiopathic scoliosis patients undergoing posterior spinal fusion: 2 doses versus antibiotics till drain removal.

Authors:  Vijay H D Kamath; Jason Pui Yin Cheung; Kin Cheung Mak; Yat Wa Wong; Wai Yuen Cheung; Keith Dip Kei Luk; Kenneth Man Chee Cheung
Journal:  Eur Spine J       Date:  2016-03-12       Impact factor: 3.134

7.  The combined administration of vancomycin IV, standard prophylactic antibiotics, and vancomycin powder in spinal instrumentation surgery: does the routine use affect infection rates and bacterial resistance?

Authors:  Howard Young Park; William Sheppard; Ryan Smith; Jiayang Xiao; Jonathan Gatto; Richard Bowen; Anthony Scaduto; Langston Holly; Daniel Lu; Duncan McBride; Arya Nick Shamie; Don Young Park
Journal:  J Spine Surg       Date:  2018-06

8.  Antibiotic Microbial Prophylaxis for Spinal Surgery: Comparison between 48 and 72-Hour AMP Protocols.

Authors:  Boram Kim; Seong-Hwan Moon; Eun-Su Moon; Hak-Sun Kim; Jin-Oh Park; In-Je Cho; Hwan-Mo Lee
Journal:  Asian Spine J       Date:  2010-11-24

Review 9.  The contribution of RCTs to quality management and their feasibility in practice.

Authors:  Jens Ivar Brox
Journal:  Eur Spine J       Date:  2009-05-01       Impact factor: 3.134

Review 10.  Postoperative Spine Infections.

Authors:  Paolo Domenico Parchi; Gisberto Evangelisti; Lorenzo Andreani; Federico Girardi; Lebl Darren; Andrew Sama; Michele Lisanti
Journal:  Orthop Rev (Pavia)       Date:  2015-09-28
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