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Literature DB >> 8300232

Analysis of protective and nonprotective monoclonal antibodies specific for Bordetella pertussis lipooligosaccharide.

R D Shahin¹, J Hamel, M F Leef, B R Brodeur.

Abstract

In this study, it has been determined that immunoglobulin G1 (IgG1) and IgG3 monoclonal antibodies directed to the lipooligosaccharide A of Bordetella pertussis were able to protect mice from fatal aerosol infection. No correlation was found between the bactericidal activity in vitro in the presence of complement and the protection in mice, since a bactericidal IgG3 did not elicit protection. In addition, no significant difference in protective capacity was observed with bactericidal and nonbactericidal IgG1 antibodies, indicating that bactericidal activity is not a requirement for protection mediated by certain anti-lipooligosaccharide A antibodies. A reduction in protection in C5-deficient mice was observed, suggesting a significant role for complement in certain host defense mechanisms against B. pertussis infection.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1994 PMID： 8300232 PMCID： PMC186166 DOI： 10.1128/iai.62.2.722-725.1994

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

1. Macrophage behaviour during the complaisant phase of murine pertussis.

Authors: C Cheers; D F Gray
Journal: Immunology Date: 1969-12 Impact factor: 7.397

2. Serum opsonic activity after immunization of adults with Haemophilus influenzae type b-diphtheria toxoid conjugate vaccine.

Authors: K L Cates; K H Marsh; D M Granoff
Journal: Infect Immun Date: 1985-04 Impact factor: 3.441

3. Agglutinating monoclonal antibodies that specifically recognize lipooligosaccharide A of Bordetella pertussis.

Authors: Z M Li; J L Cowell; M J Brennan; D L Burns; C R Manclark
Journal: Infect Immun Date: 1988-03 Impact factor: 3.441

Review 4. Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis.

Authors: B R Brodeur; D Martin; J Hamel; R D Shahin; C Laferrière
Journal: Springer Semin Immunopathol Date: 1993

5. The mode of action of antibody in neutrophil bactericidal activity against highly pathogenic group-B streptococci.

Authors: P H Cleat; C R Coid
Journal: Med Microbiol Immunol Date: 1984 Impact factor: 3.402

6. Effect of systemic immunization on pulmonary clearance of Haemophilus influenzae type b.

Authors: G B Toews; D A Hart; E J Hansen
Journal: Infect Immun Date: 1985-05 Impact factor: 3.441

7. Role of C5 and recruited neutrophils in early clearance of nontypable Haemophilus influenzae from murine lungs.

Authors: G B Toews; W C Vial; E J Hansen
Journal: Infect Immun Date: 1985-10 Impact factor: 3.441

8. Two physically and serologically distinct lipopolysaccharide profiles in strains of Bordetella pertussis and their phenotype variants.

Authors: M S Peppler
Journal: Infect Immun Date: 1984-01 Impact factor: 3.441

9. Serum antibody prevents lethal murine influenza pneumonitis but not tracheitis.

Authors: R Ramphal; R C Cogliano; J W Shands; P A Small
Journal: Infect Immun Date: 1979-09 Impact factor: 3.441

10. Characterization of the protective capacity and immunogenicity of the 69-kD outer membrane protein of Bordetella pertussis.

Authors: R D Shahin; M J Brennan; Z M Li; B D Meade; C R Manclark
Journal: J Exp Med Date: 1990-01-01 Impact factor: 14.307

16 in total

1. Maternal immunity provides protection against pertussis in newborn piglets.

Authors: Shokrollah Elahi; Rachelle M Buchanan; Lorne A Babiuk; Volker Gerdts
Journal: Infect Immun Date: 2006-05 Impact factor: 3.441

2. An improved immunofluorescent reagent for rapid, direct detection of Bordetella pertussis.

Authors: D Martin; P McNicol; R Marchand; P Lebel; M S Peppler; B R Brodeur
Journal: Can J Infect Dis Date: 1995-01

3. Toward a new vaccine for pertussis.

Authors: John B Robbins; Rachel Schneerson; Joanna Kubler-Kielb; Jerry M Keith; Birger Trollfors; Evgeny Vinogradov; Joseph Shiloach
Journal: Proc Natl Acad Sci U S A Date: 2014-02-20 Impact factor: 11.205

Review 4. Antigenic analysis of the saccharide moiety of the lipooligosaccharide of Bordetella pertussis.

Authors: B R Brodeur; D Martin; J Hamel; R D Shahin; C Laferrière
Journal: Springer Semin Immunopathol Date: 1993

5. Serum immunoglobulin G antibody responses to Bordetella pertussis lipooligosaccharide and B. parapertussis lipopolysaccharide in children with pertussis and parapertussis.

Authors: B Trollfors; T Lagergård; J Taranger; E Bergfors; R Schneerson; J B Robbins
Journal: Clin Diagn Lab Immunol Date: 2001-09

6. Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets.

Authors: Shokrollah Elahi; David R Thompson; Jill Van Kessel; Lorne A Babiuk; Volker Gerdts
Journal: Infect Immun Date: 2017-03-23 Impact factor: 3.441

7. Role of gamma interferon in natural clearance of Bordetella pertussis infection.

Authors: J Barbic; M F Leef; D L Burns; R D Shahin
Journal: Infect Immun Date: 1997-12 Impact factor: 3.441

8. Adjuvanticity and protective immunity elicited by Bordetella pertussis antigens encapsulated in poly(DL-lactide-co-glycolide) microspheres.

Authors: R Shahin; M Leef; J Eldridge; M Hudson; R Gilley
Journal: Infect Immun Date: 1995-04 Impact factor: 3.441

9. Characterization of human bactericidal antibodies to Bordetella pertussis.

Authors: A A Weiss; P S Mobberley; R C Fernandez; C M Mink
Journal: Infect Immun Date: 1999-03 Impact factor: 3.441

10. Bordetella bronchiseptica-mediated cytotoxicity to macrophages is dependent on bvg-regulated factors, including pertactin.

Authors: C B Forde; X Shi; J Li; M Roberts
Journal: Infect Immun Date: 1999-11 Impact factor: 3.441