OBJECTIVE: To study whether intravenous disodium-ethylene diamine tetraacetic acid (EDTA) affects blood lipids in patients with intermittent claudication. DESIGN: Double-blind, randomized, placebo-controlled trial. PARTICIPANTS: Twenty-nine patients with intermittent claudication (systolic ankle-brachial blood pressure index < 0.8; pain free walking distance 50-200 m). INTERVENTION: 3 g EDTA or placebo (isotonic saline) per infusion over a period of 5-9 weeks to a total of 57 g EDTA. Patients received vitamins, minerals and trace-elements daily. RESULTS: 14 patients received EDTA and 15 placebo. There was no statistically significant difference in the plasma concentration of cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or triglyceride between the 2 groups. CONCLUSION: Treatment with EDTA does not alter blood lipids in patients with intermittent claudication.
RCT Entities:
OBJECTIVE: To study whether intravenous disodium-ethylene diamine tetraacetic acid (EDTA) affects blood lipids in patients with intermittent claudication. DESIGN: Double-blind, randomized, placebo-controlled trial. PARTICIPANTS: Twenty-nine patients with intermittent claudication (systolic ankle-brachial blood pressure index < 0.8; pain free walking distance 50-200 m). INTERVENTION: 3 g EDTA or placebo (isotonic saline) per infusion over a period of 5-9 weeks to a total of 57 g EDTA. Patients received vitamins, minerals and trace-elements daily. RESULTS: 14 patients received EDTA and 15 placebo. There was no statistically significant difference in the plasma concentration of cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or triglyceride between the 2 groups. CONCLUSION: Treatment with EDTA does not alter blood lipids in patients with intermittent claudication.
Authors: Maria Vanessa Villarruz-Sulit; Rachel Forster; Antonio L Dans; Flordeliza N Tan; Dennis V Sulit Journal: Cochrane Database Syst Rev Date: 2020-05-05