Multiple circumferential skin folds and other anomalies: a problem in syndrome delineation.

Three patients with multiple ring creases of the extremities are reported. Evidence to date points to aetiological heterogeneity. The skin folds may occur as an isolated abnormality or together with other patterns of malformation, making-up various syndromes that need to be further delineated. One type is associated with autosomal dominant inheritance. This striking abnormality usually resolves with time.