Literature DB >> 8298645

Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes.

C Tyler-Smith1, R J Oakey, Z Larin, R B Fisher, M Crocker, N A Affara, M A Ferguson-Smith, M Muenke, O Zuffardi, M A Jobling.   

Abstract

We have localized the DNA sequences required for mitotic centromere function on the human Y chromosome. Analysis of 33 rearranged Y chromosomes allowed the centromere to be placed in interval 8 of a 24-interval deletion map. Although this interval is polymorphic in size, it can be as small as approximately 500kb. It contains alphoid satellite DNA and approximately 300kb of adjacent Yp sequences. Chromosomes with rearrangements in this region were analysed in detail. Two translocation chromosomes and one monocentric isochromosome had breakpoints within the alphoid array. Of 12 suppressed Y centromeres on translocation chromosomes and dicentric isochromosomes that were also analysed two showed deletions one of which only removed alphoid DNA. These results indicate that alphoid DNA is a functional part of the Y chromosome centromere.

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Year:  1993        PMID： 8298645     DOI： 10.1038/ng1293-368

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  54 in total

1.  1st International Conference on the Mammalian Centromere. Taichung, Taiwan, 2-4 October 1998. Abstracts.

Authors: 
Journal:  Chromosome Res       Date:  1998-12       Impact factor: 5.239

2.  Two male patients with ring Y: definition of an interval in Yq contributing to Turner syndrome.

Authors:  M Tzancheva; R Kaneva; P Kumanov; G Williams; C Tyler-Smith
Journal:  J Med Genet       Date:  1999-07       Impact factor: 6.318

3.  A molecular and FISH analysis of structurally abnormal Y chromosomes in patients with Turner syndrome.

Authors:  D O Robinson; P Dalton; P A Jacobs; K Mosse; M M Power; D H Skuse; J A Crolla
Journal:  J Med Genet       Date:  1999-04       Impact factor: 6.318

4.  Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array.

Authors:  Jennifer M Spence; Ricky Critcher; Thomas A Ebersole; Manuel M Valdivia; William C Earnshaw; Tatsuo Fukagawa; Christine J Farr
Journal:  EMBO J       Date:  2002-10-01       Impact factor: 11.598

Review 5.  Topoisomerase II: untangling its contribution at the centromere.

Authors:  Andrew C G Porter; Christine J Farr
Journal:  Chromosome Res       Date:  2004       Impact factor: 5.239

6.  The transcribed 165-bp CentO satellite is the major functional centromeric element in the wild rice species Oryza punctata.

Authors:  Wenli Zhang; Chuandeng Yi; Weidong Bao; Bin Liu; Jiajun Cui; Hengxiu Yu; Xiaofeng Cao; Minghong Gu; Min Liu; Zhukuan Cheng
Journal:  Plant Physiol       Date:  2005-08-19       Impact factor: 8.340

7.  Molecular distinction between true centric fission and pericentric duplication-fission.

Authors:  Jo Perry; Sara Nouri; Phung La; Art Daniel; Zhanhe Wu; Stuart Purvis-Smith; Emma Northrop; K H Andy Choo; Howard R Slater
Journal:  Hum Genet       Date:  2005-01-27       Impact factor: 4.132

8.  Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.

Authors:  Danielle V Irvine; David J Amor; Jo Perry; Nicolas Sirvent; Florence Pedeutour; K H Andy Choo; Richard Saffery
Journal:  Chromosome Res       Date:  2004       Impact factor: 5.239

9.  Retrotransposon accumulation and satellite amplification mediated by segmental duplication facilitate centromere expansion in rice.

Authors:  Jianxin Ma; Scott A Jackson
Journal:  Genome Res       Date:  2005-12-14       Impact factor: 9.043

10.  Structure of the chromosome VII centromere region in Neurospora crassa: degenerate transposons and simple repeats.

Authors:  E B Cambareri; R Aisner; J Carbon
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272
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