| Literature DB >> 8298644 |
S Park1, A Bernard, K E Bove, D A Sens, D J Hazen-Martin, A J Garvin, D A Haber.
Abstract
Nephrogenic rests consist of foci of primitive renal cells, typically microscopic, that are found within the normal kidney tissue of children with Wilms' tumour. To study the relationship between nephrogenic rests and the associated tumours, we screened these lesions for mutations in the 11p13 Wilms' tumour suppressor gene, WT1. In two cases in which the Wilms' tumour contained a somatic WT1 mutation, the nephrogenic rest had the identical mutation. Nephrogenic rests and Wilms' tumours are therefore topographically distinct lesions that are clonally derived from an early renal stem cell. Inactivation of WT1 appears to be an early genetic event which can lead to the formation of nephrogenic rests, enhancing the probability that additional genetic hits will lead to Wilms' tumour.Entities:
Mesh：
Year: 1993 PMID： 8298644 DOI： 10.1038/ng1293-363
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330