OBJECTIVE: To provide accurate estimates of the risk of lymphoma in patients with dermatitis herpetiformis. DESIGN: Comparison of observed and expected incidence of cancer in patients with dermatitis herpetiformis. SUBJECTS: 976 patients aged 4 to 97 years with no clinical signs of coeliac disease who were admitted to hospital between 1963 and 1983. SETTING: Data from Swedish Cancer Registry. MAIN OUTCOME MEASURES: Incidence and type of cancer. RESULTS: 106 cancers were diagnosed in 94 patients. The relative risk was 1.4 (95% confidence interval 1.1 to 1.7) in male patients and 1.2 (0.8 to 1.7) in female patients. When the individual cancer sites were analysed a significant risk was found only for malignant, non-Hodgkin's lymphoma in male patients, with a relative risk of 5.4 (2.2 to 11.1). CONCLUSIONS: The risk of lymphoma is greater in male patients with dermatitis herpetiformis, and this calls for increased surveillance in these patients.
OBJECTIVE: To provide accurate estimates of the risk of lymphoma in patients with dermatitis herpetiformis. DESIGN: Comparison of observed and expected incidence of cancer in patients with dermatitis herpetiformis. SUBJECTS: 976 patients aged 4 to 97 years with no clinical signs of coeliac disease who were admitted to hospital between 1963 and 1983. SETTING: Data from Swedish Cancer Registry. MAIN OUTCOME MEASURES: Incidence and type of cancer. RESULTS: 106 cancers were diagnosed in 94 patients. The relative risk was 1.4 (95% confidence interval 1.1 to 1.7) in male patients and 1.2 (0.8 to 1.7) in female patients. When the individual cancer sites were analysed a significant risk was found only for malignant, non-Hodgkin's lymphoma in male patients, with a relative risk of 5.4 (2.2 to 11.1). CONCLUSIONS: The risk of lymphoma is greater in male patients with dermatitis herpetiformis, and this calls for increased surveillance in these patients.
Authors: J N Leonard; W F Tucker; J S Fry; C A Coulter; A W Boylston; R M McMinn; G P Haffenden; A F Swain; L Fry Journal: Br Med J (Clin Res Ed) Date: 1983-01-01
Authors: P Vineis; P Crosignani; C Sacerdote; A Fontana; G Masala; L Miligi; O Nanni; V Ramazzotti; S Rodella; E Stagnaro; R Tumino; C Viganò; C Vindigni; A S Costantini Journal: J Epidemiol Community Health Date: 2000-06 Impact factor: 3.710
Authors: Thorvardur R Halfdanarson; Alberto Rubio-Tapia; Kay M Ristow; Thomas M Habermann; Joseph A Murray; David J Inwards Journal: Clin Gastroenterol Hepatol Date: 2010-09-17 Impact factor: 11.382